ArticleActa orthopaedica2023
Increased mortality after total hip prosthetic joint infection is mainly caused by the comorbidities rather than the infection itself.
Article in Acta orthopaedica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical Factors Associated with 90-Day Mortality in Patients Receiving Colistin Therapy for Multidrug-Resistant Gram-Negative Periprosthetic Joint Infection.Journal of clinical medicine · 2026Article
- Effects of Malnutrition on Perioperative Outcomes of Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.Arthroplasty today · 2025Article
- 30-day Mortality Following Revision of Hip Arthroplasty, A Cohort Study Based on the Swedish Perioperative Registry 2017-2022.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Cause of death following revision for periprosthetic joint infection or major aseptic revision in total hip and knee arthroplasty.Journal of bone and joint infection · 2025Article
- Treatment of Periprosthetic Joint Infection with Intravenous Vancomycin: Do We Hit the Target?Antibiotics (Basel, Switzerland) · 2024Article
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5 authors.
Funding
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Abstract
background and purposePeriprosthetic joint infection (PJI) is a feared complication of arthroplasty surgery. There is controversy as to whether PJI also correlates with increased mortality. Our aim was to investigate in a nationwide cohort if PJI is an independent risk factor for dying. PATIENTS AND
methodsWe performed a retrospective cohort study based on data from the Swedish Hip Arthroplasty Register (SHAR). All patients with a revision THA performed between 1998 and 2017 were included. The outcome is mortality; exposure is PJI according to SHAR. The control group was study participants who underwent aseptic revision. Confounders were age, sex, diagnosis, and comorbidity according to the Elixhauser index. The outcome was analyzed with a Cox proportional hazards model.
results4,943 PJI revisions and 12,529 non-infected revisions were included in the analysis. The median follow-up time was 4.1 years. In the PJI group, 1,972 patients died and in the control group, 4,512. The incidence rate ratio was 1.19 (95% confidence interval [CI] 1.13-1.25), the crude hazard ratio (HR) 1.19 (CI 1.13-1.25), and the adjusted HR 1.05 (CI 0.99-1.12) for the exposed versus the unexposed group. The strongest confounder was comorbidity.
conclusionThe increased mortality risk after revision due to PJI is mainly caused by the comorbidity of the patient, rather than by the infection itself.
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