Evidence map›Paper›PMID 37753513›Full record

ArticleEuropean journal of obstetrics & gynecology and reproductive biology: X2023

Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model.

H Situmorang, A Hestiantoro, S Purbadi, P E Wuyung, R A Werdhani, A Harahap, W Permadi, M Sahlan, W Hadisaputra

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Article in European journal of obstetrics & gynecology and reproductive biology: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

H SitumorangFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
A HestiantoroFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
S PurbadiFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
P E WuyungFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
R A WerdhaniFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
A HarahapFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.
W PermadiFaculty of Medicine, University of Padjadjaran, Sumedang, Indonesia.
M SahlanDepartment of Chemical Engineering, University of Indonesia, Central Jakarta, Indonesia.
W HadisaputraFaculty of Medicine, University of Indonesia, Central Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endometriosis has a major impact on women's quality of life. The two primary pathologies are chronic inflammation and altered apoptotic activity. Sulawesi propolis has been shown to have known anti-inflammatory and pro-apoptotic properties in other diseases. Objective: To investigate the effects of Sulawesi propolis in the rat endometriosis model. Methods: An autologous endometriosis model was created in 60 female Wistar rats by laparotomy. Rats were divided into four groups ( Results: A significant difference was seen in endometriotic tissue growth between the P50 group and the CG, with the greatest reduction in the P50 6-week (P50-6) group, reaching 70.66% of the initial area. Highest Bax/Bcl-2 mRNA expression was shown in the P50-4 and P100-4 groups, highest caspase-3 expression was shown in the P50-2 and P50-4 groups, and lowest IL-1B expression was shown in the P50-4 group; all differed significantly from the CG. No significant difference in PGE2S mRNA was found between the groups. Conclusion: Sulawesi propolis extract suppressed endometriotic tissue growth in the rat model by increasing apoptotic activity. The effects were time-dependent, with 50 mg/kg BW as the optimal dose.

Indexed as

ApoptoticChronic inflammationEndometriosisPropolisRats

Identifiers

PMID37753513
PMCPMC10518513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.