Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does.

Eric C Leszczynski, Nicole E Schwartz, Ashley C McPeek, Katharine D Currie, David P Ferguson, Theodore Garland

Abstract read

In one paragraph

Article in Sports medicine and health science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Eric C LeszczynskiDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.

Nicole E SchwartzDepartment of Evolution, Ecology, and Organismal Biology, University of California Riverside, Riverside, CA, USA.

Ashley C McPeekDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.

Katharine D CurrieDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.

David P FergusonDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.

Theodore GarlandDepartment of Evolution, Ecology, and Organismal Biology, University of California Riverside, Riverside, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity engagement results in a variety of positive health outcomes, including a reduction in cardiovascular disease risk partially due to eccentric remodeling of the heart. The purpose of this investigation was to determine if four replicate lines of High Runner mice that have been selectively bred for voluntary exercise on wheels have a cardiac phenotype that resembles the outcome of eccentric remodeling. Adult females (average age 55 days) from the 4 High Runner and 4 non-selected control lines were anaesthetized via vaporized isoflurane, then echocardiographic images were collected and analyzed for structural and functional differences. High Runner mice in general had lower ejection fractions compared to control mice lines (2-tailed

Indexed as

Cardiovascular diseaseEchocardiographyHeartVoluntary physical activityWheel running

Identifiers

PMID37753423

DOI10.1016/j.smhs.2023.07.003

PMCPMC10518799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.