Evidence map›Paper›PMID 37753358›Full record

ArticleFuture science OA2023

Molecular mechanisms of colistin- and multidrug-resistance in bacteria among patients with hospital-acquired infections.

Surbhi Khurana, Amit Katiyar, Mamta Puraswani, Divya Sharma, Kamini Walia, Rajesh Malhotra, Purva Mathur

Open access · goldAbstract read
In one paragraph

Article in Future science OA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Surbhi KhuranaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi.ORCID https://orcid.org/0000-0002-4263-5368
Amit KatiyarCentralized Core Research Facility, Bioinformatics Facility, All India Institute of Medical Sciences, New Delhi, India.
Mamta PuraswaniDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi.
Divya SharmaDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi.
Kamini WaliaEpidemiology & Communicable Diseases, Indian Council of Medical Research.
Rajesh MalhotraDepartment of Orthopedics, Chief, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi.
Purva MathurDepartment of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi.ORCID https://orcid.org/0000-0003-4429-3688
All India Institute of Medical Sciences · INIndian Council of Medical Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The increasing burden of resistance in Gram-negative bacteria (GNB) is becoming a major issue for hospital-acquired infections. Therefore, understanding the molecular mechanisms is important. Methodology: Resistance genes of phenotypically colistin-resistant GNB (n = 60) were determined using whole genome sequencing. Antimicrobial susceptibility patterns were detected by Vitek®2 & broth microdilution. Results: Of these phenotypically colistin-resistant isolates, 78% were also genetically resistant to colistin. Activation of efflux pumps, and point-mutations in Discussion: These results, in combination with rapid diagnostic methods, will help us better advice appropriate antimicrobial regimens.

Indexed as

antimicrobial resistancecolistin-resistant bacteriahospital-acquired infectionsmultidrug resistancewhole genome sequencing

Identifiers

PMID37753358
PMCPMC10518808
OpenAlexW4386217957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.