ArticleJournal of medical imaging (Bellingham, Wash.)2023
Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities.
Article in Journal of medical imaging (Bellingham, Wash.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Volume rendering technique and high-resolution microCT: 3D exploration of the cochlear anatomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography.Scientific reports · 2025Article
- Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities.Journal of medical imaging (Bellingham, Wash.) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Purpose: Assessing the complex three-dimensional (3D) structure of the cochlea is crucial to understanding the fundamental aspects of signal transduction in the inner ear and is a prerequisite for the development of novel cochlear implants. X-ray phase-contrast computed tomography offers destruction-free 3D imaging with little sample preparation, thus preserving the delicate structure of the cochlea. The use of heavy metal stains enables higher contrast and resolution and facilitates segmentation of the cochlea. Approach: For μ-CT of small animal and human cochlea, we explore the heavy metal osmium tetroxide (OTO) as a radiocontrast agent and delineate laboratory Results: Image contrast for soft tissue in an aqueous solution is insufficient under the in-house conditions, whereas the OTO stain increases contrast for lipid-rich tissue components, such as the myelin sheaths in nervous tissue, enabling contrast-based rendering of the different components of the auditory nervous system. The overall morphology of the cochlea with the three scalae and membranes is very well represented. Further, the image quality of the reconstructions improves significantly when a phase retrieval scheme is used, which is also suitable for non-ideal laboratory Conclusions: The OTO stain is suitable for 3D imaging of small animal and human cochlea with laboratory
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