Evidence map›Paper›PMID 37753171›Full record

ArticlePeerJ2023

Urine proteomic analysis of the rat e-cigarette model.

Yuqing Liu, Ziyun Shen, Chenyang Zhao, Youhe Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuqing LiuGene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing, China.
Ziyun ShenGene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing, China.
Chenyang ZhaoGene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing, China.
Youhe GaoGene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing, China.
Beijing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We were curious if the urinary proteome could reflect the effects of e-cigarettes on the organism. Methods: Urine samples were collected from a rat e-cigarette model before, during, and after two weeks of e-cigarette smoking. Urine proteomes before and after smoking of each rat were compared individually, while the control group was set up to rule out differences caused by rat growth and development. Results: Fetuin-B, a biomarker of chronic obstructive pulmonary disease (COPD), and annexin A2, which is recognized as a multiple tumour marker, were identified as differential proteins in five out of six smoking rats on day 3. To our surprise, odourant-binding proteins expressed in the olfactory epithelium were also found and were significantly upregulated. Pathways enriched by the differential proteins include the apelin signalling pathway, folate biosynthesis pathway, arachidonic acid metabolism, chemical carcinogenesis-DNA adducts and chemical carcinogenesis-reactive oxygen species. They have been reported to be associated with immune system, cardiovascular system, respiratory system, Conclusions: Urinary proteome could reflect the effects of e-cigarettes in rats.

Indexed as

Electronic Nicotine Delivery SystemsAnimalsCarcinogenesisProteomeProteomicsRatsUrinalysisProteomeE-cigarette modelOdorant-binding proteinProteomicsUrine

Identifiers

PMID37753171
PMCPMC10519197
OpenAlexW4386964002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.