Evidence map›Paper›PMID 37753161›Full record

ArticleJCPP advances2023

Categorical versus dimensional structure of autism spectrum disorder: A multi-method investigation.

Thomas W Frazier, Lacey Chetcuti, Fouad A Al-Shaban, Nick Haslam, Iman Ghazal, Eric W Klingemier, Mohammed Aldosari, Andrew J O Whitehouse, Eric A Youngstrom, Antonio Y Hardan and 1 more

Open access · goldAbstract read
In one paragraph

Article in JCPP advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Thomas W FrazierDepartment of Psychology John Carroll University University Heights Ohio USA.ORCID https://orcid.org/0000-0002-6951-2667
Lacey ChetcutiOlga Tennison Autism Research Centre School of Psychology and Public Health La Trobe University Melbourne Victoria Australia.ORCID https://orcid.org/0000-0002-9360-0851
Fouad A Al-ShabanNeurological Disorders Research Center Qatar Biomedical Research Institute Hamad Bin Khalifa University Doha Qatar.
Nick HaslamMelbourne School of Psychological Sciences University of Melbourne Melbourne Victoria Australia.
Iman GhazalNeurological Disorders Research Center Qatar Biomedical Research Institute Hamad Bin Khalifa University Doha Qatar.
Eric W KlingemierCaregiver Experience Cleveland Clinic Cleveland Ohio USA.
Mohammed AldosariNeurological Institute Cleveland Clinic Cleveland Ohio USA.
Andrew J O WhitehouseTelethon Kids Institute University of Western Australia Perth Western Australia Australia.
Eric A YoungstromDepartment of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Antonio Y HardanDepartment of Psychiatry and Behavioral Sciences Stanford University Stanford California USA.
Mirko UljarevićMelbourne School of Psychological Sciences University of Melbourne Melbourne Victoria Australia.
Cleveland Clinic · USHamad bin Khalifa University · QAThe University of Melbourne · AUJohn Carroll University · USLa Trobe University · AUStanford University · USThe Kids Research Institute Australia · AUUniversity of North Carolina at Chapel Hill · US

Funding

A Big Data Approach Toward the Development of a New Quantitative Measure of Restricted and Repetitive BehaviorsR21MH121876 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO, JO, BOOIL · 2020 to 2021
$434k
Identification of RDoC Social Communication Sub-Constructs Using Existing DatasetsR03MH111846 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2017 to 2018
$157k
NIMH NIH HHS R03 MH111846NIMH NIH HHS R21 MH121876
6 · The paper itself

Abstract

Background: A key question for any psychopathological diagnosis is whether the condition is continuous or discontinuous with typical variation. The primary objective of this study was to use a multi-method approach to examine the broad latent categorical versus dimensional structure of autism spectrum disorder (ASD). Method: Data were aggregated across seven independent samples of participants with ASD, other neurodevelopmental disorders (NDD), and non-ASD/NDD controls (aggregate Results: Across all indicator sets and analytic methods, there was strong support for categorical structure corresponding closely to ASD diagnosis. Consistent with notions of substantial phenotypic heterogeneity, the ASD category had a wide range of symptom severity. Despite the examination of a large sample with a wide range of IQs in both genders, males and children with lower IQ were over-represented in the ASD category, similar to observations in diagnosed cases. Conclusions: Our findings provide strong support for categorical structure corresponding closely to ASD diagnosis. The present results bolster the use of well-diagnosed and representative ASD groups within etiologic and clinical research, motivating the ongoing search for major drivers of the ASD phenotype. Despite the categorical structure of ASD, quantitative symptom measurements appear more useful for examining relationships with other factors.

Indexed as

autismcategoricaldimensionallatenttaxometric

Identifiers

PMID37753161
PMCPMC10519739
OpenAlexW4321446117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.