Evidence map›Paper›PMID 37753150›Full record

ArticleJCPP advances2023

Twins Early Development Study (TEDS): A genetically sensitive investigation of mental health outcomes in the mid-twenties.

Celestine Lockhart, Joanna Bright, Yasmin Ahmadzadeh, Gerome Breen, Shannon Bristow, Andy Boyd, Johnny Downs, Matthew Hotopf, Elisavet Palaiologou, Kaili Rimfeld and 6 more

Open access · goldAbstract read
In one paragraph

Article in JCPP advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  19. Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Celestine LockhartSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-6584-3696
Joanna BrightSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-0695-0491
Yasmin AhmadzadehSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0003-1333-1661
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0003-2053-1792
Shannon BristowSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-0896-781X
Andy BoydPopulation Health Sciences Institute Bristol Medical School University of Bristol Bristol UK.ORCID https://orcid.org/0000-0002-8614-3728
Johnny DownsDepartment of Child and Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.ORCID https://orcid.org/0000-0002-8061-295X
Matthew HotopfSouth London and Maudsley NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0002-3980-4466
Elisavet PalaiologouSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0003-4707-3349
Kaili RimfeldSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0001-5139-065X
Jessye MaxwellSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-3158-7479
Margherita MalanchiniSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-7257-6119
Tom A McAdamsSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-6825-3499
Andrew McMillanSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0009-0000-1101-3729
Robert PlominSocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0002-0756-3629
Thalia C EleySocial, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London Camberwell London UK.ORCID https://orcid.org/0000-0001-6458-0700
King's College London · GBQueen Mary University of London · GBUniversity of Bristol · GB

Funding

Medical Research Council MC_PC_20030Medical Research Council MC_PC_20059Medical Research Council MR/M021475/1Medical Research Council MR/V012878/1Wellcome Trust
6 · The paper itself

Abstract

The Twins Early Development Study (TEDS) is a longitudinal study following a cohort of twins born 1994-1996 in England and Wales. Of the 13,759 families who originally consented to take part, over 10,000 families remain enrolled in the study. The current focus of TEDS is on mental health in the mid-twenties. Making use of over 25 years of genetically sensitive data, TEDS is uniquely placed to explore the longitudinal genetic and environmental influences on common mental health disorders in early adulthood. This paper outlines recent data collection efforts supporting this work, including a cohort-wide mental health assessment at age 26 and a multi-phase Covid-19 study. It will also provide an update on data linkage efforts and the Children of TEDS (CoTEDS) project.

Indexed as

behavioural geneticslongitudinal studiesmental healthTEDStwins

Identifiers

PMID37753150
PMCPMC10519737
OpenAlexW4361268920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.