ArticleSubstance use & misuse2024
Resilience Phenotypes and Psychological Functioning among Individuals with Opioid Use Disorder.
Article in Substance use & misuse, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundOpioid use disorder (OUD) is a heterogeneous disorder. However, there is a lack of deep phenotyping investigations focusing on important psychological constructs such as resilience that may impact OUD. The present study aimed to investigate the relationship between trait resilience and the five-factor model of personality (FFM) among individuals with opioid use disorder (OUD). We also explored whether the FFM and trait resilience form specific phenotypes associated with psychological functioning.
methodsThis secondary analysis of an epigenetic study included participants of African ancestry (
resultsLinear regression revealed a significant relationship between resilience (CD-RISC-25 score) and the FFM,
conclusionsThese findings suggest associations between the FFM and trait resilience among individuals with OUD. Two distinct "resilience phenotypes" emerged, with high-resilience individuals displaying less stress, anxiety, and depressive symptoms. Results highlight the clinical importance of resilience as a potential target for intervention in people with OUD.
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