Evidence map›Paper›PMID 37752455›Full record

ArticleBMC pediatrics2023

Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents.

Ali Shaker, Soheila Shekari, Mobina Zeinalabedini, Zahra Salimi, Zahra Roumi, Khadijeh Abbasi Mobarakeh, Ali Shamsi-Goushki, Mohammad Masoumvand, Mohammad Keshavarz Mohammadian, Pegah Samani and 5 more

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In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Ali ShakerDepartment of Cellular and Molecular Biology, Mashhad Branch, Islamic Azad Universityof Mashhad, Mashhad, Iran.
Soheila ShekariDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mobina ZeinalabediniDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Zahra SalimiNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Zahra RoumiDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Khadijeh Abbasi MobarakehFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Ali Shamsi-GoushkiDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad MasoumvandDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Keshavarz MohammadianDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Pegah SamaniDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Ghasem Azizi-TabeshGenomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hanieh ShafaeiSchool of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Saeid DoaeiDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Doaei@gums.ac.ir.
Naser KalantariDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam GholamalizadehCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Islamic Azad University, Science and Research Branch · IRMashhad University of Medical Sciences · IRNational Nutrition and Food Technology Research Institute · IRShahid Beheshti University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRGuilan University of Medical Sciences · IRIsfahan University of Medical Sciences · IRIslamic Azad University, Mashhad · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle Nucleotide Polymorphisms (SNPs) of the Fat mass and obesity-associated (FTO) gene may be associated with obesity by regulating appetite. The present study aimed to investigate the relationship between FTO genotype and resistance to eating in male adolescents.

methodsThe present cross-sectional study included 246 adolescent boys in Tehran, Iran, who were assessed for self-efficacy related to weight control using the Weight Efficacy Lifestyle (WEL), questionnaire, food intake using the Food Frequency Questionnaire (FFQ), physical activity using the International Physical Activity Questionnaire (IPAQ), and anthropometric indices using Bio-Impedance Analyzer (BIA). Moreover, the participants underwent genotyping for the rs9930506 polymorphism of the FTO gene, and the relationship between FTO genotype and resistance to eating was investigated using different models of multiple linear regression.

resultsAccording to our findings, there was a significant reverse relationship between the FTO rs9930506 genotype and resistance to eating (β: -0.16, P = 0.01). Moreover, the relationship was still significant after adjusting for age, nutritional knowledge, BMI, and mother's BMI, educational level, and occupational status.

conclusionAccording to our results, the FTO genotype had a significant effect on resistance to eating and food desires. However, there is a need for further studies to evaluate the underlying mechanisms of the effects of the FTO gene on appetite and obesity.

Indexed as

ObesityPolymorphism, Single NucleotideAdolescentAlpha-Ketoglutarate-Dependent Dioxygenase FTOCross-Sectional StudiesGenotypeHumansIranMaleAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanAppetiteFTO geneGenotypeMale adolescentObesity

Identifiers

PMID37752455
PMCPMC10521541
OpenAlexW4387057575

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.