Evidence map›Paper›PMID 37752412›Full record

ArticleBMC molecular and cell biology2023

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats.

Xiaoming Liu, Mengya Liu, Huan Liu, Hui Yuan, Yong Wang, Xiaoman Chen, Jianguo Li, Xiujun Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoming Liu *Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China.
Mengya Liu *Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China.
Huan LiuDepartment of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China.
Hui YuanDepartment of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China.
Yong WangSchool of forensic medicine, Shanxi Medical University, Taiyuan, 030001, P. R. China.
Xiaoman ChenSchool of forensic medicine, Shanxi Medical University, Taiyuan, 030001, P. R. China.
Jianguo LiDepartment of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China.
Xiujun QinDepartment of Radiology and Environmental Medicine, China Institute for Radiation Protection, CAEA Center of Excellence on Nuclear Technology Applications for Non-Clinical Evaluation for Radiopharmaceutical, Shanxi Key Laboratory for Pharmaceutical Toxicology & Radiation Injury Pharmaceuticals, CNNC Key Laboratory for Radiotoxicology and Preclinical Assessment of Radiopharmaceuticals, Taiyuan, 030006, P. R. China. xiujunqin@163.com.
National Institute for Radiological Protection · CNShanxi Medical University · CN

Funding

Natural Science Foundation of Shanxi Province 202203021211005 and 201801D1213
6 · The paper itself

Abstract

backgroundHydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by coupling the brain metabolomics and biological target network methods. METHODS AND

resultsHRW significantly improves the cognitive impairment in rats exposed to ionizing radiation. Based on metabolomics and biological network results, we identified 54 differential metabolites and 93 target genes. The KEGG pathway indicates that glutathione metabolism, ascorbic acid and aldehyde acid metabolism, pentose and glucuronic acid interconversion, and glycerophospholipid metabolism play important roles in ionizing radiation therapy.

conclusionOur study has systematically elucidated the molecular mechanism of HRW against ionizing radiation, which can be mediated by modulating targets, pathways and metabolite levels. This provides a new perspective for identifying the underlying pharmacological mechanism of HRW.

Indexed as

BrainCognitive DysfunctionAnimalsHydrogenRatsTechnologyWaterHydrogenWaterBiological networkBrain tissue metabolomicsHydrogen-rich waterIonizing radiation

Identifiers

PMID37752412
PMCPMC10523633
OpenAlexW4387050814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.