Evidence map›Paper›PMID 37752374›Full record

ArticleBiological trace element research2024

Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress-Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats.

Manal Alosaimi, Yasmina M Abd-Elhakim, Amany Abdel-Rahman Mohamed, Mohamed M M Metwally, Tarek Khamis, Wafa S Alansari, Areej A Eskandrani, Walaa M Essawi, Marwa M Awad, Rehab A A El-Shaer and 3 more

Abstract read
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In one paragraph

Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Molecular medicine reports · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Manal AlosaimiDepartment of Basic Health Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Yasmina M Abd-ElhakimDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. yasmina_forensic@hotmail.com.
Amany Abdel-Rahman MohamedDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. amanyrahman292@gmail.com.
Mohamed M M MetwallyDepartment of Pathology and Clinical pathology, Faculty of Veterinary Medicine, King Salman International University, Ras sudr, Egypt.
Tarek KhamisPharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt.
Wafa S AlansariBiochemistry Department, Faculty of Science, University of Jeddah, 21577, Jeddah, Saudi Arabia.
Areej A EskandraniChemistry Department, College of Science, Taibah University, Medina, 30002, Saudi Arabia.
Walaa M EssawiDepartment of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan, 81528, Egypt.
Marwa M AwadPhysiology Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt.
Rehab A A El-ShaerPhysiology Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt.
Sarah IbrahimHuman Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt.
Mohamed A NassanDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, PO Box 11099, Taif, 21944, Saudi Arabia.
Aya Sh MetwallyDepartment of Pharmacology, Faculty of Veterinary Medicine, Aswan University, Aswan, 81528, Egypt.
Tanta University · EGZagazig University · EGAswan University · EGJeddah University · SAKing Salman International UniversityPrincess Nourah bint Abdulrahman University · SATaibah University · SATaif University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their distinctive properties, several eco-friendly metal oxide nanoparticles were assessed for their possible cardioprotective properties. Acrylamide (ACD), a pervasive chemical in food and the environment, has been linked to cardiac toxicity. Therefore, this study examined the probable protective effect of green synthesized zinc oxide nanoparticles (GS-ZNPs) against ACD-oral exposure-induced cardiac damage in rats. For 60 days, 40 male Sprague-Dawley rats were separated into four sets that orally administered distilled water, 10-mg GS-ZNP/kg b.w., 20-mg ACD/kg b.w., or GS-ZNP + ACD. Then, cardiac damage indicators comprising CPK, CK-MB, cTn, and LDH were assessed. Besides, cardiac tissues' architecture, oxidative stress indicators, and Zn content were evaluated. The mRNA expression of the ERS-related genes, including ATF3, ATF4, ATF6, XBP-1, CHOP, JNKs, and BiP, were determined. Moreover, ERS-dependent anti-apoptotic (BCL-2) and apoptotic (Caspase-3 and BAX) genes mRNA expression were analyzed. The results showed that GS-ZNP significantly alleviated the increased ACD-induced serum cardiac damage indicators, MDA tissue content, and histopathological changes. Furthermore, the ACD-induced reduction of antioxidants and Zn heart contents were significantly reestablished by GS-ZNP. Furthermore, the ACD-induced upregulation of the ERS-encoding genes and apoptotic genes was reversed by GS-ZNP. Besides, the ACD-induced BCL-2 downregulation was counteracted by GS-ZNP. Overall, GS-ZNP could be a biologically potent compound to alleviate ACD's cardiotoxic effects, possibly by controlling the ERS and apoptosis-related genes and antioxidant activity.

Indexed as

AcrylamideApoptosisEndoplasmic Reticulum StressProto-Oncogene Proteins c-bcl-2Rats, Sprague-DawleySignal TransductionTranscription Factor CHOPZinc OxideActivating Transcription Factor 3AnimalsGreen Chemistry TechnologyHeart InjuriesMaleMetal NanoparticlesNanoparticlesOxidative StressAcrylamideActivating Transcription Factor 3Bcl2 protein, ratDdit3 protein, ratProto-Oncogene Proteins c-bcl-2Transcription Factor CHOPZinc OxideAcrylamideApoptosisEndoplasmic reticulum stressHeartmRNAZinc oxide nanoparticles

Identifiers

PMID37752374
OpenAlexW4387077076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.