Evidence map›Paper›PMID 37752368›Full record

ArticleDigestive diseases and sciences2023

Intestinal Barrier and Gut Microbiota in Patients with Overlapping Irritable Bowel Syndrome and Functional Dyspepsia.

Aleksandra Kovaleva, Elena Poluektova, Roman Maslennikov, Anna Karchevskaya, Oleg Shifrin, Andrey Kiryukhin, Aleksandr Tertychnyy, Leonid Kovalev, Marina Kovaleva, Olga Lobanova and 3 more

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Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. The Duodenal Microenvironment in Functional Dyspepsia.Journal of neurogastroenterology and motility · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Aleksandra KovalevaSechenov University, Moscow, Russia, 119435.
Elena PoluektovaSechenov University, Moscow, Russia, 119435.
Roman MaslennikovSechenov University, Moscow, Russia, 119435. maslennikov_r_v@staff.sechenov.ru.ORCID 0000-0001-7513-1636
Anna KarchevskayaSechenov University, Moscow, Russia, 119435.
Oleg ShifrinSechenov University, Moscow, Russia, 119435.
Andrey KiryukhinSechenov University, Moscow, Russia, 119435.
Aleksandr TertychnyySechenov University, Moscow, Russia, 119435.
Leonid KovalevA.N. Bach Institute of Biochemistry, Leninsky Prospekt, 33, Bld. 2, Moscow, Russia, 119071.
Marina KovalevaA.N. Bach Institute of Biochemistry, Leninsky Prospekt, 33, Bld. 2, Moscow, Russia, 119071.
Olga LobanovaSechenov University, Moscow, Russia, 119435.
Anna KudryavtsevaEngelhardt Institute of Molecular Biology, Vavilova St., 32, Bld. 1, Moscow, Russia, 119991.
George KrasnovEngelhardt Institute of Molecular Biology, Vavilova St., 32, Bld. 1, Moscow, Russia, 119991.
Vladimir IvashkinSechenov University, Moscow, Russia, 119435.
Sechenov University · RUA N Bach Institute of Biochemistry · RUEngelhardt Institute of Molecular Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisturbances in the intestinal barrier and gut dysbiosis have been observed in patients with functional bowel diseases.

aimsTo investigate the correlation between biomarkers of intestinal barrier disorders at different layers and the severity of symptoms in patients with overlapping diarrhea-predominant irritable bowel syndrome and functional dyspepsia (IDFO), as well as with gut microbiota taxa.

methodsThis study included 45 patients with IDFO and 16 healthy controls. Endoscopy with biopsy of the duodenum and sigmoid colon (SC) was performed to count intraepithelial lymphocytes (IELs) and mucosal eosinophils (subepithelial layer), assess fatty acid binding protein (FABP; epithelial layer) level, and stain for mucin-2 (MUC-2; pre-epithelial layer). Composition of the gut microbiota was evaluated using 16S rRNA gene sequencing.

resultsPatients with IDFO exhibited an increase in biomarkers of intestinal barrier disorders at all layers studied. IEL count in the duodenum was correlated with the severity of bloating (r = 0.336; p = 0.024) and, in the SC, was correlated with tenesmus severity (r = 0.303; p = 0.042). FABP-1 level in the SC was correlated with the severity of diarrhea (r = 0.577; p = 0.001), and FABP-5 concentration in the SC was correlated with abdominal distension (r = 0.477; p = 0.010). MUC-2 concentration in the duodenum was correlated with the severity of heartburn (r = 0.572; p = 0.025) and burning sensation in the epigastrium (r = 0.518; p = 0.048). All biomarkers of intestinal barrier permeability were correlated with the abundance of some gut microbiota taxa.

conclusionPatients with IDFO exhibited disrupted intestinal barrier function in all layers, which was associated with clinical symptom severity and changes in the gut microbiota.

Indexed as

DyspepsiaGastrointestinal MicrobiomeIrritable Bowel SyndromeBiomarkersDiarrheaDysbiosisHumansRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16SDiarrheaDysbiosisFunctional digestive diseaseGut barrierMicrobiomeMicrobiota

Identifiers

PMID37752368
OpenAlexW4387039779

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.