Evidence map›Paper›PMID 37752232›Full record

ArticleScientific reports2023

PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury.

Supinder S Bedi, Michael C Scott, Max A Skibber, Akshita Kumar, Henry W Caplan, Hasen Xue, David Sequeira, Alison L Speer, Fanni Cardenas, Franciska Gudenkauf and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Supinder S BediDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA. Supinder.Bedi@uth.tmc.edu.
Michael C ScottDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Max A SkibberDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Akshita KumarDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Henry W CaplanDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Hasen XueDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
David SequeiraDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Alison L SpeerDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Fanni CardenasDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Franciska GudenkaufDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Karen UrayDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
Amit K SrivastavaDivision of Hematology, Department of Medicine, Cardeza Foundation for Hematologic Research, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.
Alan R ProssinDepartment of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Houston, TX, USA.
Charles S CoxDepartment of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.230, Houston, TX, 77030, USA.
The University of Texas Health Science Center at Houston · USTexas Medical Center · USThomas Jefferson University · US

Funding

ROLE OF THE GUT IN POST INJURY MULTIPLE ORGAN FAILURET32GM008792 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Charles S Cox · 2001 to 2026
$5.2M
NIGMS NIH HHS T32 GM008792
6 · The paper itself

Abstract

Traumatic brain injury (TBI) results in activated microglia. Activated microglia can be measured in vivo by using positron emission topography (PET) ligand peripheral benzodiazepine receptor standardized uptake values (PBR28suv). Cell based therapies have utilized autologous bone marrow mononuclear cells (BMMNCs) to attenuate activated microglia after TBI. This study aims to utilize in vivo PBR28suv to assess the efficacy of BMMNCs therapy after TBI. Seventy-two hours after CCI injury, BMMNCs were harvested from the tibia and injected via tail-vein at 74 h after injury at a concentration of 2 million cells per kilogram of body weight. There were three groups of rats: Sham, CCI-alone and CCI-BMMNCs (AUTO). One hundred twenty days after injury, rodents were imaged with PBR28 and their cognitive behavior assessed utilizing the Morris Water Maze. Subsequent ex vivo analysis included brain volume and immunohistochemistry. BMMNCs therapy attenuated PBR28suv in comparison to CCI alone and it improved spatial learning as measured by the Morris Water Maze. Ex vivo analysis demonstrated preservation of brain volume, a decrease in amoeboid-shaped microglia in the dentate gyrus and an increase in the ratio of ramified to amoeboid microglia in the thalamus. PBR28suv is a viable option to measure efficacy of BMMNCs therapy after TBI.

Indexed as

Brain Injuries, TraumaticMicrogliaAnimalsBone MarrowElectronsPositron-Emission TomographyRats

Identifiers

PMID37752232
PMCPMC10522669
OpenAlexW4387038242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.