Evidence map›Paper›PMID 37752166›Full record

ArticleScientific reports2023

Pressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats.

Mihály Ruppert, Sevil Korkmaz-Icöz, Bettina Benczik, Bence Ágg, Dávid Nagy, Tímea Bálint, Alex Ali Sayour, Attila Oláh, Bálint András Barta, Kálmán Benke and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Role of non-coding RNAs in OOncology letters · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Mihály RuppertExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary. ruppertmis@gmail.com.
Sevil Korkmaz-IcözDepartment of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Bettina BenczikPharmahungary Group, Szeged, Hungary.
Bence ÁggPharmahungary Group, Szeged, Hungary.
Dávid NagyExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Tímea BálintExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Alex Ali SayourExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Attila OláhExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Bálint András BartaExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Kálmán BenkeExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Péter FerdinandyPharmahungary Group, Szeged, Hungary.
Matthias KarckDepartment of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Béla MerkelyExperimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Tamás Radovits *Experimental Research Laboratory, Heart and Vascular Center, Semmelweis University, Városmajor u. 68, 1122, Budapest, Hungary.
Gábor Szabó *Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Semmelweis University · HUHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although systolic function characteristically shows gradual impairment in pressure overload (PO)-evoked left ventricular (LV) hypertrophy (LVH), rapid progression to congestive heart failure (HF) occurs in distinct cases. The molecular mechanisms for the differences in maladaptation are unknown. Here, we examined microRNA (miRNA) expression and miRNA-driven posttranscriptional gene regulation in the two forms of PO-induced LVH (with/without systolic HF). PO was induced by aortic banding (AB) in male Sprague-Dawley rats. Sham-operated animals were controls. The majority of AB animals demonstrated concentric LVH and slightly decreased systolic function (termed as AB

Indexed as

Heart Failure, SystolicMicroRNAsAnimalsFragile X Messenger Ribonucleoprotein 1Gene Expression RegulationHypertrophy, Left VentricularMaleRatsRats, Sprague-DawleyRNA, MessengerWeight GainFmr1 protein, ratFragile X Messenger Ribonucleoprotein 1MicroRNAsRNA, Messenger

Identifiers

PMID37752166
PMCPMC10522609
OpenAlexW4387034974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.