ArticleNature communications2023
Social memory deficit caused by dysregulation of the cerebellar vermis.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.Neuroscience and biobehavioral reviews · 2025Pooled it
- Predictive and instructive cerebellar encoding of dopamine reward drives motivated behavior.Nature neuroscience · 2026Article
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice.Science advances · 2026Article
- Correlation Analysis of Clinical, Imaging, and Genetic Etiologies in Pediatric Hereditary Cerebellar Atrophy: A Single-Center Study.Molecular genetics & genomic medicine · 2026Article
- Cerebellar tDCS Modulates Corticocortical Functional Networks in a Regionally Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Early diagnosis of Alzheimer's Disease: Graph theoretical analysis of cerebellar network features based on 18F-AV45 PET.PloS one · 2026Article
- Hippocampal-cortical interactions in the consolidation of social memory.Nature communications · 2025Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
- The Genetics of Cerebellar Structure and Associations With Cognitive Performance: A Twin Magnetic Resonance Imaging Study.Human brain mapping · 2025Article
- Article
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.bioRxiv : the preprint server for biology · 2025Article
- Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Neurofunctional correlates of emotional dysregulation in adolescent Crohn's disease: a resting-state fMRI preliminary investigation.Frontiers in neuroscience · 2025Article
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.Nature communications · 2024Article
- Purkinje cell ablation and Purkinje cell-specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses.The Journal of physiology · 2024Article
- Social and emotional learning in the cerebellum.Nature reviews. Neuroscience · 2024Review
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- Article
- The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Social recognition memory (SRM) is a key determinant of social interactions. While the cerebellum emerges as an important region for social behavior, how cerebellar activity affects social functions remains unclear. We selectively increased the excitability of molecular layer interneurons (MLIs) to suppress Purkinje cell firing in the mouse cerebellar vermis. Chemogenetic perturbation of MLIs impaired SRM without affecting sociability, anxiety levels, motor coordination or object recognition. Optogenetic interference of MLIs during distinct phases of a social recognition test revealed the cerebellar engagement in the retrieval, but not encoding, of social information. c-Fos mapping after the social recognition test showed that cerebellar manipulation decreased brain-wide interregional correlations and altered network structure from medial prefrontal cortex and hippocampus-centered to amygdala-centered modules. Anatomical tracing demonstrated hierarchical projections from the central cerebellum to the social brain network integrating amygdalar connections. Our findings suggest that the cerebellum organizes the neural matrix necessary for SRM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.