ArticleNature communications2023
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models.
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In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- A supramolecular complex of palmitoylated Orai C-terminal peptide and cyclodextrin targets the plasma membrane to reduce store-operated calcium channel activity.Materials advances · 2026Article
- Review
- Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.Journal of orthopaedic surgery and research · 2026Article
- Stem cell factor 248 shapes ILC2 transcriptional programs and promotes mucosal inflammation in allergic asthma.Frontiers in immunology · 2026Article
- The role of calcium homeostasis dysregulation in allergic rhinitis.Frontiers in immunology · 2026Review
- The Expanding Role of ILC2s in Allergic Airways Disease.Allergy · 2026Review
- Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.Frontiers in medicine · 2026Review
- Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming.Frontiers in immunology · 2026Article
- The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis.The Journal of clinical investigation · 2025Article
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease.Immune network · 2025Review
- The role of ILC2s in asthma combined with atopic dermatitis: bridging the gap from research to clinical practice.Frontiers in immunology · 2025Review
- Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024Review
- SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism.Cellular & molecular immunology · 2024Article
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus.Cell reports · 2024Article
- Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.The Journal of experimental medicine · 2024Article
- ORAI CaBiomolecules · 2024Review
- Fatty acid oxidation in immune function.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Emily HowardDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin P HurrellDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Doumet Georges HelouDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-5835-9214
Pedram Shafiei-JahaniDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Spyridon HasiakosDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jacob PainterDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0002-3034-095X
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0002-2821-9245
Omid AkbariDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. akbari@usc.edu.ORCID 0000-0002-4359-9725
University of Southern California · USUniversity of California, Los Angeles · US
Funding
Study the link of autophagy dysfunction to allergic and neutrophilic asthma onsetR01HL151493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2020 to 2024
$3.6MGene Expression in Myeloma CellsR01AI030653 · NIAID · HUNTER COLLEGE · PI ECKHARDT, LAUREL A · 1990 to 2010
$3.4MMaternal effect on offspring immunity against hepatitis B virusR01AI145813 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, OU, J.-H. JAMES · 2019 to 2023
$3.2MRole of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid CellsR01HL159804 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2022 to 2025
$3.0MInduction of cells and pathways that promote respiratory tolerance in allergic asthmaR01HL144790 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2019 to 2022
$2.6MTranscriptional and metabolomic regulation of IL-10 in pulmonary ILC2sR01AI169687 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OMID AKBARI · 2022 to 2026
$2.1MMechanism underlying regulation of Ca2+ signaling in local effector T cellsR01AI146615 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2024
$1.8MRegulation of the STING pathway under sterile conditionsR01AI146352 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2020 to 2023
$1.6MUCLA Dental Specialty PhD ProgramK12DE027830 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne L Kapila · 2018 to 2026
$1.5MDistinctive role of ORAI3 channels in the effector T cell responseR21AI149236 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2021
$429kNHLBI NIH HHS R01 HL144790NHLBI NIH HHS R01 HL151493NHLBI NIH HHS R01 HL159804NIAID NIH HHS R01 AI030653NIAID NIH HHS R01 AI145813NIAID NIH HHS R01 AI146352NIAID NIH HHS R01 AI146615NIAID NIH HHS R01 AI169687NIAID NIH HHS R21 AI149236NIDCR NIH HHS K12 DE027830
Abstract
Ca
Indexed as
AsthmaImmunity, InnateAnimalsHomeostasisHumansInflammationLymphocytesMiceORAI1 ProteinORAI1 Protein
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.