Evidence map›Paper›PMID 37752123›Full record

ArticleNature communications2023

Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models.

Daniel J Butler, Alexander P Keim, Shantanu Ray, Eiman Azim

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel J ButlerMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA.ORCID 0000-0002-3268-9848
Alexander P KeimMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA.ORCID 0000-0002-5025-1348
Shantanu RayMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Eiman AzimMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, 92037, USA. eazim@salk.edu.ORCID 0000-0002-1015-1772

Funding

Spinal Circuits for the Control of Dextrous MovementU19NS112959 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$14.3M
Neural control of skilled movements: an ethological dissection of genetically tractable mammalian motor circuitsDP2NS105555 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2017 to 2022
$3.7M
Defining the anatomical, molecular and functional logic of internal copy circuits involved in dexterous forelimb behaviorsR01NS111479 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$2.9M
Functional dissection of cerebellar output circuits that orchestrate limb motor controlRF1NS128898 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN, CHEN, ALBERT · 2022 to 2022
$2.3M
Functional dissection of cerebellar output circuits that orchestrate limb motor controlR01NS128898 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EIMAN AZIM, Albert Chen · 2025 to 2026
$1.3M
Control of Skilled Forelimb Movements by Cerebellar Feedback CircuitsR00NS088193 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2016 to 2018
$747k
Control of Skilled Forelimb Movements by Cerebellar Feedback CircuitsK99NS088193 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AZIM, EIMAN · 2014 to 2015
$180k
NINDS NIH HHS DP2 NS105555NINDS NIH HHS K99 NS088193NINDS NIH HHS R00 NS088193NINDS NIH HHS R01 NS111479NINDS NIH HHS R01 NS128898NINDS NIH HHS RF1 NS128898NINDS NIH HHS U19 NS112959
6 · The paper itself

Abstract

Deep learning-based markerless tracking has revolutionized studies of animal behavior. Yet the generalizability of trained models tends to be limited, as new training data typically needs to be generated manually for each setup or visual environment. With each model trained from scratch, researchers track distinct landmarks and analyze the resulting kinematic data in idiosyncratic ways. Moreover, due to inherent limitations in manual annotation, only a sparse set of landmarks are typically labeled. To address these issues, we developed an approach, which we term GlowTrack, for generating orders of magnitude more training data, enabling models that generalize across experimental contexts. We describe: a) a high-throughput approach for producing hidden labels using fluorescent markers; b) a multi-camera, multi-light setup for simulating diverse visual conditions; and c) a technique for labeling many landmarks in parallel, enabling dense tracking. These advances lay a foundation for standardized behavioral pipelines and more complete scrutiny of movement.

Indexed as

Motion CaptureMovementBiomechanical PhenomenaMotion

Identifiers

PMID37752123
PMCPMC10522643

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.