Evidence map›Paper›PMID 37752027›Full record

ReviewAtherosclerosis2023

Sex-specific differences in cardiovascular risk factors and implications for cardiovascular disease prevention in women.

Aardra Rajendran, Anum S Minhas, Brigitte Kazzi, Bhavya Varma, Eunjung Choi, Aarti Thakkar, Erin D Michos

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Atherosclerosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 7 pooled it
54.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 7 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
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  6. Guideline
  7. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aardra RajendranDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anum S MinhasDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brigitte KazziDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bhavya VarmaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eunjung ChoiDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aarti ThakkarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Erin D MichosDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: edonnell@jhmi.edu.
Johns Hopkins University · US

Funding

Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
NCATS NIH HHS KL2 TR003099
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality for women globally. Sex differences exist in the relative risks conferred by traditional CVD risk factors, including diabetes, hypertension, obesity, and smoking. Additionally, there are female-specific risk factors, including age of menarche and menopause, polycystic ovary syndrome, infertility and the use of assisted reproductive technology, spontaneous pregnancy loss, parity, and adverse pregnancy outcomes, as well as female-predominant conditions such as autoimmune diseases, migraines, and depression, that enhance women's cardiovascular risk across the lifespan. Along with measurement of traditional risk factors, these female-specific factors should also be ascertained as a part of cardiovascular risk assessment to allow for a more comprehensive overview of the risk for developing cardiometabolic disorders and CVD. When present, these factors can identify women at elevated cardiovascular risk, who may benefit from more intensive preventive interventions, including lifestyle changes and/or pharmacotherapy such as statins. This review describes sex differences in traditional risk factors and female-specific/female-predominant risk factors for CVD and examines the role of coronary artery calcium scores and certain biomarkers that can help further risk stratify patients and guide preventive recommendations.

Indexed as

Abortion, SpontaneousCardiovascular DiseasesFemaleHeart Disease Risk FactorsHumansMalePregnancyRisk FactorsSex CharacteristicsAutoimmune diseaseMenopauseMigrainePregnancyPreventionRisk factorsSex differencesWomen's cardiovascular health

Identifiers

PMID37752027
PMCPMC10841060
OpenAlexW4386419381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.