Evidence map›Paper›PMID 37751937›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Timing and level of educational attainment and late-life cognition in the KHANDLE study.

Yenee Soh, Rachel A Whitmer, Elizabeth Rose Mayeda, M Maria Glymour, Chloe W Eng, Rachel L Peterson, Kristen M George, Ruijia Chen, Charles P Quesenberry, Dan M Mungas and 2 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Observational
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  9. Review
  10. Article
  11. Article
  12. Timing and level of educational attainment and late-life cognition in the KHANDLE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yenee SohKaiser Permanente Division of Research, Oakland, California, USA.ORCID 0000-0001-5200-7325
Rachel A WhitmerKaiser Permanente Division of Research, Oakland, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Chloe W EngDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Rachel L PetersonSchool of Public and Community Health Sciences, University of Montana, Missoula, Montana, USA.
Kristen M GeorgeDepartment of Public Health Sciences, University of California, Davis, California, USA.
Ruijia ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Charles P QuesenberryKaiser Permanente Division of Research, Oakland, California, USA.
Dan M MungasDepartment of Neurology, School of Medicine, University of California, Davis, California, USA.
Charles S DeCarliDepartment of Neurology, School of Medicine, University of California, Davis, California, USA.
Paola GilsanzKaiser Permanente Division of Research, Oakland, California, USA.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEE-WAY JIN · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PATRICK C. HEUVELINE · 2016 to 2026
$6.9M
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaR01AG066132 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GILSANZ, PAOLA · 2019 to 2023
$2.0M
Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related DementiasR00AG073457 · NIA · UNIVERSITY OF MONTANA · PI PETERSON, RACHEL LYNNE · 2022 to 2024
$724k
Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep DisturbanceK00AG068431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, RUIJIA · 2021 to 2024
$330k
NIA NIH HHS K00 AG068431NIA NIH HHS P30 AG072972NIA NIH HHS R00 AG073457NIA NIH HHS R01 AG052132NIA NIH HHS R01 AG066132NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

introductionThe timing of educational attainment may modify its effects on late-life cognition, yet most studies evaluate education only at a single time point.

methodsKaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study cohort participants (N = 554) reported educational attainment (dichotomized at any college education) at two time points, and we classified them as having low, high, or later-life high educational attainment. Linear mixed-effects models estimated associations between educational attainment change groups and domain-specific cognitive outcomes (z-standardized).

resultsCompared to low educational attainment, high (β= 0.59 SD units; 95% confidence interval [CI]: 0.39, 0.79) and later-life high educational attainment (β = 0.22; 95% CI: 0.00, 0.44) were associated with higher executive function. Only high educational attainment was associated with higher verbal episodic memory (β = 0.27; 95% CI: 0.06, 0.48). DISCUSSION: Level and timing of educational attainment are both associated with domain-specific cognition. A single assessment for educational attainment may inadequately characterize protective associations with late-life cognition. HIGHLIGHTS: Few studies have examined both level and timing of educational attainment on cognition. Marginalized populations are more likely to attain higher education in adulthood. Higher educational attainment in late life is also associated with higher cognition.

Indexed as

Healthy AgingMemory, EpisodicCognitionEducational StatusHumansLife Change Eventsadulthood educationcognitive changecognitive declinecognitive functioneducational attainment timing

Identifiers

PMID37751937
PMCPMC10842991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.