Evidence map›Paper›PMID 37751922›Full record

ArticleBlood research2023

ABO blood group and rhesus factor association with inpatient COVID-19 mortality and severity: a two-year retrospective review.

Alexander T Phan, Ari A Ucar, Aldin Malkoc, Janie Hu, Luke Buxton, Alan W Tseng, Fanglong Dong, Julie P T Nguyễn, Arnav P Modi, Ojas Deshpande and 4 more

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In one paragraph

Article in Blood research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander T PhanDepartment of Internal Medicine, Arrowhead Regional Medical Center, CA, USA.
Ari A UcarDepartment of Internal Medicine, Arrowhead Regional Medical Center, CA, USA.
Aldin MalkocDepartment of General Surgery, Arrowhead Regional Medical Center, CA, USA.
Janie HuDepartment of Internal Medicine, Arrowhead Regional Medical Center, CA, USA.
Luke BuxtonDepartment of Critical Care Medicine, Arrowhead Regional Medical Center, CA, USA.
Alan W TsengDepartment of Internal Medicine, Arrowhead Regional Medical Center, CA, USA.
Fanglong DongDepartment of Graduate Medical Education, Arrowhead Regional Medical Center, CA, USA.
Julie P T NguyễnSchool of Medicine, California University of Science and Medicine, Colton, CA, USA.
Arnav P ModiSchool of Medicine, California University of Science and Medicine, Colton, CA, USA.
Ojas DeshpandeSchool of Medicine, California University of Science and Medicine, Colton, CA, USA.
Johnson LaySchool of Medicine, California University of Science and Medicine, Colton, CA, USA.
Andrew KuSchool of Medicine, California University of Science and Medicine, Colton, CA, USA.
Dotun OgunyemiDepartment of Graduate Medical Education, Arrowhead Regional Medical Center, CA, USA.
Sarkis ArabianDepartment of Critical Care Medicine, Arrowhead Regional Medical Center, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early reports have indicated a relationship between ABO and rhesus blood group types and infection with SARS-CoV-2. We aim to examine blood group type associations with COVID-19 mortality and disease severity. Methods: This is a retrospective chart review of patients ages 18 years or older admitted to the hospital with COVID-19 between January 2020 and December 2021. The primary outcome was COVID-19 mortality with respect to ABO blood group type. The secondary outcomes were 1. Severity of COVID-19 with respect to ABO blood group type, and 2. Rhesus factor association with COVID-19 mortality and disease severity. Disease severity was defined by degree of supplemental oxygen requirements (ambient air, low-flow, high-flow, non-invasive mechanical ventilation, and invasive mechanical ventilation). Results: The blood type was collected on 596 patients with more than half (54%, N=322) being O+. The ABO blood type alone was not statistically associated with mortality (P=0.405), while the RH blood type was statistically associated with mortality ( Conclusion: ABO blood type is not associated with COVID-19 severity and mortality. Rhesus factor status is associated with COVID-19 severity and mortality. Rhesus negative patients were associated with increased mortality risk.

Indexed as

COVID-19Infectious diseaseMechanical ventilationPulmonary medicineSARS-CoV-2

Identifiers

PMID37751922
PMCPMC10548287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.