Evidence map›Paper›PMID 37751919›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Changes to hypothalamic volume and associated subunits during gender-affirming hormone therapy.

Melisande E Konadu, Murray B Reed, Ulrike Kaufmann, Patricia A Handschuh, Benjamin Spurny-Dworak, Manfred Klöbl, Clemens Schmidt, Godber, M Godbersen, Elisa Briem and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Melisande E KonaduFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Murray B ReedFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Ulrike KaufmannFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Patricia A HandschuhFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Benjamin Spurny-DworakFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Manfred KlöblFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Clemens SchmidtFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
GodberFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
M GodbersenFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Elisa BriemFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
René SeigerFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Pia Baldinger-MelichFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Georg S KranzFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Rupert LanzenbergerFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz) rupert.lanzenberger@meduniwien.ac.at.
Marie SpiesFrom the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
Hong Kong Polytechnic University · HKComprehensive Cancer Center Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong its pleiotropic properties, gender-affirming hormone therapy (GHT) affects regional brain volumes. The hypothalamus, which regulates neuroendocrine function and associated emotional and cognitive processes, is an intuitive target for probing GHT effects. We sought to assess changes to hypothalamus and hypothalamic subunit volumes after GHT, thereby honouring the region's anatomical and functional heterogeneity.

methodsIndividuals with gender dysphoria and cisgender controls underwent 2 MRI measurements, with a median interval of 145 days (interquartile range [IQR] 128.25-169.75 d, mean 164.94 d) between the first and second MRI. Transgender women (TW) and transgender men (TM) underwent the first MRI before GHT and the second MRI after approximately 4.5 months of GHT, which comprised estrogen and anti-androgen therapy in TW or testosterone therapy in TM. Hypothalamic volumes were segmented using FreeSurfer, and effects of GHT were tested using repeated-measures analysis of covariance.

resultsThe final sample included 106 participants: 38 TM, 15 TW, 32 cisgender women (CW) and 21 cisgender men (CM). Our analyses revealed group × time interaction effects for total, left and right hypothalamus volume, and for several subunits (left and right inferior tubular, left superior tubular, right anterior inferior, right anterior superior, all LIMITATIONS: We did not address the influence of transition-related psychological and behavioural changes.

conclusionOur results suggest a subunit-specific effect of GHT on hypothalamus volumes in TW. This finding is in accordance with previous reports of positive and negative effects of androgens and estrogens, respectively, on cerebral volumes.

Indexed as

EmotionsGender DysphoriaFemaleHumansHypothalamusMaleTestosteroneTestosterone

Identifiers

PMID37751919
PMCPMC10521920
OpenAlexW4387050767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.