Evidence map›Paper›PMID 37751917›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of

Tiziana Quarto, Annalisa Lella, Pasquale Di Carlo, Antonio Rampino, Vittoria Paladini, Marco Papalino, Raffaella Romano, Leonardo Fazio, Daniela Marvulli, Teresa Popolizio and 3 more

Open access · diamondAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. MicroRNAs as biomarkers and molecular mediators of cognitive dysfunction in schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Tiziana Quarto *From the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Annalisa Lella *From the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Pasquale Di CarloFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Antonio RampinoFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Vittoria PaladiniFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Marco PapalinoFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Raffaella RomanoFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Leonardo FazioFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Daniela MarvulliFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Teresa PopolizioFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Giuseppe BlasiFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Giulio PergolaFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola).
Alessandro BertolinoFrom the Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy (Quarto, Lella, Di Carlo, Rampino, Paladini, Papalino, Romano, Fazio, Marvulli, Blasi, Pergola, Bertolino); the Department of Humanities, University of Foggia, Foggia, Italy (Quarto); the Psychiatry Unit, Bari University Hospital, Bari, Italy (Rampino, Blasi, Bertolino); the LUM (Fazio); the IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Popolizio); the Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD (Pergola) alessandro.bertolino@uniba.it giulio.pergola@uniba.it.
Lieber Institute for Brain Development · USIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Bari Aldo Moro · ITCasa Sollievo della Sofferenza · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized by anomalies in emotion processing. We aimed to identify genetic variants associated with heritable brain activity during processing of facial emotions among healthy participants and to explore the impact of these identified variants among patients with schizophrenia.

methodsWe conducted a data-driven stepwise study including samples of healthy twins, unrelated healthy participants and patients with schizophrenia. Participants approached or avoided pictures of faces with negative emotional valence during functional magnetic resonance imaging (fMRI).

resultsWe investigated 3 samples of healthy participants - including 28 healthy twin pairs, 289 unrelated healthy participants (genome-wide association study [GWAS] discovery sample) and 90 unrelated healthy participants (replication sample) - and 1 sample of 48 patients with schizophrenia. Among healthy twins, we identified the amygdala as the brain region with the highest heritability during processing of angry faces (heritability estimate 0.54, LIMITATIONS: The limited sample size available for GWAS analyses may require further replication of results.

conclusionOur data-driven approach shows preliminary evidence that amygdala activity, as evaluated with our task, is heritable. Our genetic associations preliminarily suggest a role for

Indexed as

MicroRNAsSchizophreniaAmygdalaAngerCase-Control StudiesGenome-Wide Association StudyHumansMicroRNAsMIRN137 microRNA, human

Identifiers

PMID37751917
PMCPMC10521919
OpenAlexW4387059885

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.