Evidence map›Paper›PMID 37751747›Full record

ArticleCell host & microbe2023

Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART.

Riddhima Banga, Francesco Andrea Procopio, Erica Lana, Gregory T Gladkov, Isabelle Roseto, Elizabeth M Parsons, Xiaodong Lian, Marie Armani-Tourret, Maxime Bellefroid, Ce Gao and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  6. HIV controllers, lessons learnt from the lymphoid tissues.Current opinion in HIV and AIDS · 2026
    Review
  7. Targeting PD-1Science advances · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Roadmap for spatial transcriptomics of HIV in tissues.Current opinion in HIV and AIDS · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. HIV Cure: How Far We Have Come?Indian journal of microbiology · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 5 institutions in 3 countries.

Riddhima BangaServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Francesco Andrea ProcopioServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Erica LanaServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Gregory T GladkovRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Isabelle RosetoRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Elizabeth M ParsonsRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Xiaodong LianRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Marie Armani-TourretRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Maxime BellefroidRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Ce GaoRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Annamaria KauzlaricTranslational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.
Mathilde FoglieriniServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Oscar Alfageme-AbelloServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Susanna H M SlukaNewborn Screening Switzerland, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Olivia MunozServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Andrea MastrangeloServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Craig FenwickServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Yannick MullerServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Catherine Gerald MkindiIfakara Health Institute, Bagamoyo, United Republic of Tanzania; Department of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Claudia DaubenbergerDepartment of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, 4001 Basel, Switzerland.
Matthias CavassiniServices of Infectious Diseases, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Rafael TrunfioServices of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Sébastien DégliseServices of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Jean-Marc CorpatauxServices of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Mauro DelorenziTranslational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.
Mathias LichterfeldRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Giuseppe PantaleoServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Matthieu PerreauServices of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland. Electronic address: matthieu.perreau@chuv.ch.
University of Lausanne · CHRagon Institute of MGH, MIT and Harvard · USSwiss Tropical and Public Health Institute · CHBrigham and Women's Hospital · USUniversity Children's Hospital Zurich · CH

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
A Pilot Clinical Trial for HIV-1 EradicationU01AI117841 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KURITZKES, DANIEL R., LICHTERFELD, MATHIAS · 2015 to 2020
$10.7M
Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodesR01DK120387 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI LICHTERFELD, MATHIAS, YUKL, STEVEN A · 2019 to 2023
$4.1M
Selection and Evolution of HIV-1 reservoir cells in blood and tissuesR01AI152979 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ESTES, JACOB D, LICHTERFELD, MATHIAS · 2020 to 2025
$3.8M
Proteomics and phosphoproteomics analysis in HIV-1 infectionR01AI130005 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LICHTERFELD, MATHIAS · 2017 to 2021
$2.9M
Quantification of the HIV-1 Reservoir by Immuno-PCRR01AI120008 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HEREDIA, ALONSO, LICHTERFELD, MATHIAS · 2015 to 2019
$1.9M
Mentoring in patient-oriented research to finding a cure for HIV-1 infectionK24AI155233 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LICHTERFELD, MATHIAS · 2021 to 2025
$958k
NIAID NIH HHS K24 AI155233NIAID NIH HHS R01 AI120008NIAID NIH HHS R01 AI130005NIAID NIH HHS R01 AI152979NIAID NIH HHS U01 AI117841NIAID NIH HHS UM1 AI164560NIDDK NIH HHS R01 DK120387
6 · The paper itself

Abstract

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1. Notably, LN DC subpopulations isolated from HIV-infected individuals treated for up to 14 years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV infection in the presence of ART.

Indexed as

HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAnti-Retroviral AgentsCD4-Positive T-LymphocytesDendritic CellsHumansLymph NodesAnti-Retroviral Agentsdendritic cellsHIVHIV cureHIV persistenceHIV reservoirHIV single-genome sequencingintact HIVlymph nodereplication-competent virusT follicular helper cells

Identifiers

PMID37751747
PMCPMC11068440
OpenAlexW4387031054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.