Evidence map›Paper›PMID 37751619›Full record

ArticleEuropean journal of immunology2023

Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.

Mira M Chawda, Susan Ross, Ching-In Lau, Diana C Yánez, Jasmine Rowell, Peter Kilbride, Tessa Crompton

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Reconstitution of thymopoiesis via implantation of cryopreserved cultured thymus tissue into athymic recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mira M ChawdaUCL Great Ormond Street Institute of Child Health, London, UK.
Susan RossUCL Great Ormond Street Institute of Child Health, London, UK.
Ching-In LauUCL Great Ormond Street Institute of Child Health, London, UK.
Diana C YánezUCL Great Ormond Street Institute of Child Health, London, UK.
Jasmine RowellUCL Great Ormond Street Institute of Child Health, London, UK.
Peter KilbrideCytiva, Danaher Corporation, Cambridge, UK.
Tessa CromptonUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-8973-4021
Great Ormond Street Hospital · GBDanaher (United States) · US

Funding

Medical Research Council MR/S037764/1
6 · The paper itself

Abstract

Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.

Indexed as

Immune ReconstitutionThymocytesAnimalsCryopreservationHumansMiceThymus GlandClinical immunologyCryopreservationThymopoiesisThymus transplantation

Identifiers

PMID37751619
PMCPMC10946610
OpenAlexW4387037421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.