ArticleeLife2023
Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors.Neuron · 2026Article
- Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Learning reweights the decision dynamics of cortico-basal ganglia-thalamic pathways from deliberation to commitment.bioRxiv : the preprint server for biology · 2026Article
- Molecular Mechanisms of Dopaminergic Neuron Degeneration in Parkinson's Disease: A Comprehensive Review.Current neuropharmacology · 2026Review
- Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.eLife · 2025Article
- Stopping Muscle Contractions and Relaxations during Action Inhibition Involves Global and Targeted Control Dependent on Muscle State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.bioRxiv : the preprint server for biology · 2025Article
- Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders.Molecular psychiatry · 2025Review
- Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?Clinical neuropsychiatry · 2025Article
- Complementary corticostriatal circuits orchestrate action repetition and switching.Science advances · 2025Article
- Article
- Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.bioRxiv : the preprint server for biology · 2025Article
- Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.bioRxiv : the preprint server for biology · 2024Article
- Shedding light on gene therapy of Parkinson's disease in non-human primates.Innovation (Cambridge (Mass.)) · 2024Review
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2 authors.
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Abstract
The basal ganglia are known to be essential for action selection. However, the functional role of basal ganglia direct and indirect pathways in action selection remains unresolved. Here, by employing cell-type-specific neuronal recording and manipulation in mice trained in a choice task, we demonstrate that multiple dynamic interactions from the direct and indirect pathways control the action selection. While the direct pathway regulates the behavioral choice in a linear manner, the indirect pathway exerts a nonlinear inverted-U-shaped control over action selection, depending on the inputs and the network state. We propose a new center (direct)-surround (indirect)-context (indirect) 'Triple-control' functional model of basal ganglia, which can replicate the physiological and behavioral experimental observations that cannot be simply explained by either the traditional 'Go/No-go' or more recent 'Co-activation' model. These findings have important implications on understanding the basal ganglia circuitry and action selection in health and disease.
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