Evidence map›Paper›PMID 37751454›Full record

ArticlePloS one2023

Towards a potent and rapidly reversible Dexmedetomidine-based general anesthetic.

Zheng Xie, Robert Fong, Aaron P Fox

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06538584 (Caffeine Facilitates the Recovery of Dexmedetomidine Sedation for MRI in Pediatric Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06538584 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Caffeine Facilitates the Recovery of Dexmedetomidine Sedation for MRI in Pediatric Patients: a Randomized, Double-blinded and Placebo-controlled Pilot Study

TypeinterventionalSponsorUniversity of ChicagoRan2024 to 2027Enrolled100ConditionsEnhanced Recovery After Surgery in a Pediatric PopulationArmsCaffeine citrate 15mg/kg, 0.9% Sodium Citrate
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zheng XieDepartment of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, United States of America.ORCID 0000-0001-8909-8339
Robert FongDepartment of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, United States of America.
Aaron P FoxDepartment of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, IL, United States of America.
University of Chicago · US

Funding

Reversing anesthesia with CaffeineR01GM116119 · NIGMS · UNIVERSITY OF CHICAGO · PI FOX, AARON P. · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM116119
6 · The paper itself

Abstract

IN

conclusionOur results suggest that Dex supplemented with a low dose of a second agent creates a potent anesthetic that is rapidly reversed by atipamezole and caffeine.

Indexed as

Anesthetics, GeneralDexmedetomidineAnesthesia, GeneralAnesthetics, GeneralDexmedetomidine

Identifiers

PMID37751454
PMCPMC10522005
OpenAlexW4387043297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.