ArticleCell reports2023
Diversity in homeostatic calcium set points predicts retinal ganglion cell survival following optic nerve injury in vivo.
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Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
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Who cites it
11 citing papers in PubMed, 9 citations in OpenAlex.
- Identification of a natively resilient but poorly regenerating retinal ganglion cell type in the G protein-coupled receptor 88-Cre transgenic mouse.Neural regeneration research · 2026Article
- A paradoxical relationship between mitochondrial calcium regulation and retinal ganglion cell degeneration after axon damage.bioRxiv : the preprint server for biology · 2026Article
- Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation.Scientific reports · 2026Article
- Impact of Orchiectomy on Oxidative Stress-Induced Neurodegeneration in the Male Rat Retina: A Proteomic Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration.Nature communications · 2026Article
- Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Multifunctional nanoplatforms for optic nerve regeneration integrating anti-inflammatory, epigenetic, and ionic mechanisms with emerging artificial intelligence technologies.Cell biology and toxicology · 2025Review
- Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell.The Journal of physiology · 2025Article
- Effect of brimonidine on retinal ganglion cell function by in vivo calcium imaging of optic nerve crush in mice.Experimental eye research · 2025Article
- Role of store-operated CaFrontiers in aging neuroscience · 2025Review
- Primary cilia formation requires the Leigh syndrome-associated mitochondrial protein NDUFAF2.The Journal of clinical investigation · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Sean McCrackenJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael J FitzpatrickJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
Allison L HallJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Postbaccalaureate Program in Developmental Biology & Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zelun WangJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daniel KerschensteinerJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA.
Josh L MorganJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Philip R WilliamsJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: prwillia@wustl.edu.
Washington University in St. Louis · US
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4MResearch Training Program in the Vision SciencesT32EY013360 · NEI · WASHINGTON UNIVERSITY · PI SHIMING CHEN, Daniel Kerschensteiner · 2000 to 2026
$5.6MSYNAPTIC ORGANIZATION AND VISUAL PROCESSING IN INTERNEURON CIRCUITS OF THE RETINAR01EY026978 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2016 to 2026
$3.8MSynapse rescue and neuroprotection in the retinaR01EY027411 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2017 to 2026
$3.4MNeuronal plasticity in retinal circuit development and diseaseR01EY023341 · NEI · WASHINGTON UNIVERSITY · PI KERSCHENSTEINER, DANIEL · 2014 to 2022
$2.8MVisual pathway cooperation to align viewing strategies and processing specializations for predationR01EY034001 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2022 to 2026
$2.0MDevelopment and function of glomerular microcircuits in the visual thalamusR01EY029313 · NEI · WASHINGTON UNIVERSITY · PI MORGAN, JOSHUA L · 2020 to 2024
$1.9MIdentifying and leveraging strategies of inherently resilient retinal neurons to treat degenerationR01EY032908 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 2022 to 2026
$1.9MTools and approaches for functional connectomics of dense neuropilsR21EY030623 · NEI · WASHINGTON UNIVERSITY · PI KERSCHENSTEINER, DANIEL, MORGAN, JOSHUA L · 2019 to 2020
$432kNEI NIH HHS P30 EY002687NEI NIH HHS R01 EY023341NEI NIH HHS R01 EY026978NEI NIH HHS R01 EY027411NEI NIH HHS R01 EY029313NEI NIH HHS R01 EY032908NEI NIH HHS R01 EY034001NEI NIH HHS R21 EY030623NEI NIH HHS T32 EY013360NIGMS NIH HHS T32 GM007200
Abstract
Retinal ganglion cell (RGC) degeneration drives vision loss in blinding conditions. RGC death is often triggered by axon degeneration in the optic nerve. Here, we study the contributions of dynamic and homeostatic Ca
Indexed as
Optic Nerve InjuriesAnimalsAxonsCalciumCell SurvivalDisease Models, AnimalHumansOptic NerveRetinal Ganglion CellsCalciumcalcium homeostasisCP: Neurosciencein vivo imagingneuronal degenerationoptic nerve crushretinal ganglion cells
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.