ArticleEnvironmental health perspectives2023
Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Pediatric effects of forever chemicals may last for a long time.Pediatric research · 2026Review
- The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls.The Journal of clinical endocrinology and metabolism · 2026Observational
- Investigating ovarian effects of perfluorooctanoic acid in postpubertal pigs during thermal neutral and heat stress conditions.Journal of animal science · 2026Article
- Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.Frontiers in endocrinology · 2026Review
- Endocrine-disrupting chemicals and female reproductive health: a growing concern.Nature reviews. Endocrinology · 2025Review
- Environmental factors trigger pubertal development.Current opinion in pediatrics · 2025Review
- Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory.Environmental health : a global access science source · 2025Article
- Article
- PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.Environmental health perspectives · 2024Article
- Invited Perspective: PFAS and Pubertal Timing in Girls-A Maturing Literature.Environmental health perspectives · 2023Article
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7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPer- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche.
methodsIn a cohort of Greater Cincinnati (GC) and San Francisco Bay Area (SFBA) girls recruited at 6-8 years of age, clinical examinations were conducted annually or semiannually with sequential Tanner staging. PFAS concentrations were measured in the first serum sample of 704 girls. In 304 GC girls, estradiol (
resultsMedian PFOA serum concentrations in GC ( POPULATION: In multivariable Cox proportional hazard models [adjusted for race, body mass index (BMI)], increasing serum log-transformed PFOA was associated with a delay in pubarche [
conclusionsPFAS may delay pubertal onset through the intervening effects on BMI and reproductive hormones. The decreases in DHEAS and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.