Evidence map›Paper›PMID 37751048›Full record

ArticleJournal of mathematical biology2023

Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach.

Alexander Roitershtein, Reza Rastegar, Robert S Chapkin, Ivan Ivanov

Abstract read
In one paragraph

Article in Journal of mathematical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Alexander RoitershteinDepartment of Statistics, Texas A &M University, College Station, TX, 77843, USA.
Reza RastegarOccidental Petroleum Corporation, Houston, TX, 77046, USA.
Robert S ChapkinDepartment of Nutrition - Program in Integrative Nutrition & Complex Diseases, Texas A &M University, College Station, TX, 77843, USA.
Ivan IvanovDepartment of Veterinary Physiology and Pharmacology, Texas A &M University, College Station, TX, 77843, USA. iivanov@cvm.tamu.edu.ORCID 0000-0002-5323-8325

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Galen Newman · 2019 to 2026
$13.0M
Plasma membrane therapy: Disruption of Wnt associated receptor spatiotemporal organization by membrane targeted dietary bioactives (MTDB)R35CA197707 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN · 2016 to 2022
$6.3M
Nutrition, Biostatistics & Bioinformatics Training GrantT32CA090301 · NCI · TEXAS A&M UNIVERSITY · PI CARROLL, RAYMOND J. · 2016 to 2020
$712k
NCI NIH HHS R35 CA197707NCI NIH HHS T32 CA090301NIEHS NIH HHS P30 ES029067
6 · The paper itself

Abstract

We study a discrete-time multi-type Wright-Fisher population process. The mean-field dynamics of the stochastic process is induced by a general replicator difference equation. We prove several results regarding the asymptotic behavior of the model, focusing on the impact of the mean-field dynamics on it. One of the results is a limit theorem that describes sufficient conditions for an almost certain path to extinction, first eliminating the type which is the least fit at the mean-field equilibrium. The effect is explained by the metastability of the stochastic system, which under the conditions of the theorem spends almost all time before the extinction event in a neighborhood of the equilibrium. In addition to the limit theorems, we propose a maximization principle for a general deterministic replicator dynamics and study its implications for the stochastic model.

Indexed as

Biological EvolutionPopulation DynamicsStochastic ProcessesEvolutionary dynamicsFitness landscapeLyapunov functionsMetastabilityQuasi-equilibriaWright–Fisher process

Identifiers

PMID37751048
PMCPMC10586398

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.