Evidence map›Paper›PMID 37750823›Full record

ArticleAnalytical chemistry2023

Bayesian Inference Elucidates the Catalytic Competency of the SARS-CoV-2 Main Protease 3CL

Evans C Wralstad, Jessica Sayers, Ronald T Raines

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sensitive detection of SARS-CoV-2 main protease 3CLProtein science : a publication of the Protein Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Evans C WralstadDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-2281-7594
Jessica SayersDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-5780-4155
Ronald T RainesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-7164-1719
Massachusetts Institute of Technology · US

Funding

Protein ChemistryR35GM148220 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ronald T Raines · 2023 to 2026
$2.2M
Biochemical Strategy to Avert Microbial Drug ResistanceR21AI171663 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RAINES, RONALD T · 2022 to 2023
$419k
NIAID NIH HHS R21 AI171663NIGMS NIH HHS R35 GM148220
6 · The paper itself

Abstract

The main protease of SARS-CoV-2, 3CL

Indexed as

COVID-19SARS-CoV-2Antiviral AgentsBayes TheoremCatalysisCoronavirus 3C ProteasesCysteine EndopeptidasesHumansPeptide Hydrolases3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesPeptide Hydrolases

Identifiers

PMID37750823
PMCPMC10662973
OpenAlexW4387032920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.