Evidence map›Paper›PMID 37750771›Full record

ArticleRadiology2023

Association of Breast Cancer Odds with Background Parenchymal Enhancement Quantified Using a Fully Automated Method at MRI: The IMAGINE Study.

Gordon P Watt, Snekha Thakran, Janice S Sung, Maxine S Jochelson, Marc B I Lobbes, Susan P Weinstein, Angela R Bradbury, Saundra S Buys, Elizabeth A Morris, Aditya Apte and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Breast MRI to Screen Women With Extremely Dense Breasts.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  7. Application of Machine Learning to Breast MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Gordon P WattFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-2024-0015
Snekha ThakranFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-6722-6157
Janice S SungFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-9067-9840
Maxine S JochelsonFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-4012-2470
Marc B I LobbesFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-2103-6956
Susan P WeinsteinFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).
Angela R BradburyFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).
Saundra S BuysFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0003-4120-5697
Elizabeth A MorrisFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0001-5069-0992
Aditya ApteFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0001-8120-0669
Prusha PatelFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0001-9688-8873
Meghan WoodsFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0002-0514-3938
Xiaolin LiangFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).
Malcolm C PikeFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0003-4891-1199
Despina KontosFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).ORCID 0000-0001-9031-5126
Jonine L BernsteinFrom the Department of Epidemiology and Biostatistics (G.P.W., P.P., M.W., X.L., M.C.P., J.L.B.), Department of Radiology (J.S.S., M.S.J.), and Department of Medical Physics (A.A.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, Perelman Center for Advanced Medicine at the University of Pennsylvania, Philadelphia, Pa (S.T., S.P.W., A.R.B., D.K.); Department of Medical Imaging, Zuyderland Medical Center, Sittard-Geleen, the Netherlands (M.B.I.L.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.B.I.L.); GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (M.B.I.L.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (S.S.B.); and Department of Radiology, University of California Davis Medical Center, Davis, Calif (E.A.M.).
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
MRI Background Parenchymal Enhancement as a Risk Factor for Breast CancerR01CA183086 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BERNSTEIN, JONINE L., PIKE, MALCOLM C · 2014 to 2016
$2.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA183086
6 · The paper itself

Abstract

Background Background parenchymal enhancement (BPE) at breast MRI has been associated with increased breast cancer risk in several independent studies. However, variability of subjective BPE assessments have precluded its use in clinical practice. Purpose To examine the association between fully objective measures of BPE at MRI and odds of breast cancer. Materials and Methods This prospective case-control study included patients who underwent a bilateral breast MRI examination and were receiving care at one of three centers in the United States from November 2010 to July 2017. Breast volume, fibroglandular tissue (FGT) volume, and BPE were quantified using fully automated software. Fat volume was defined as breast volume minus FGT volume. BPE extent was defined as the proportion of FGT voxels with enhancement of 20% or more. Spearman rank correlation between quantitative BPE extent and Breast Imaging Reporting and Data System (BI-RADS) BPE categories assigned by an experienced board-certified breast radiologist was estimated. With use of multivariable logistic regression, breast cancer case-control status was regressed on tertiles (low, moderate, and high) of BPE, FGT volume, and fat volume, with adjustment for covariates. Results In total, 536 case participants with breast cancer (median age, 48 years [IQR, 43-55 years]) and 940 cancer-free controls (median age, 46 years [IQR, 38-55 years]) were included. BPE extent was positively associated with BI-RADS BPE (

Indexed as

Breast NeoplasmsBreastCase-Control StudiesCertificationFemaleHumansMagnetic Resonance ImagingMiddle Aged

Identifiers

PMID37750771
PMCPMC10546291
OpenAlexW4387033015

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.