ArticleJournal of Korean medical science2023
Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study.
Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Redefining Uric Acid and Cardiovascular Risk: Vascular Gout and Crystal-Driven Vascular Inflammation in Asymptomatic Hyperuricemia.JACC. Asia · 2026Review
- J-shaped associations of serum urate with all-cause and cause-specific mortality in diabetes: mediation by kidney function.Acta diabetologica · 2026Article
- The relationship between cardiometabolic index and hyperuricemia and gout in Korean adults: the 8th Korean National Health and Nutrition Examination Survey (2019-2021).Clinical rheumatology · 2026Article
- Study on the evaluation of left atrial structure and function in patients with H-type hypertension using 4D automated left atrial quantitative.BMC cardiovascular disorders · 2026Article
- Serum uric acid variability and short-term mortality in chronic kidney disease: a retrospective cohort study with independent replication in MIMIC-IV.Frontiers in nutrition · 2026Article
- Additive Manufacturing of Customized Flexible Wearable Sensors for Sweat Analysis with Bespoke, Low-Cost Conductive TPU.ACS measurement science au · 2025Article
- Uric acid can be a true cause of hypertension, not a simple bystander.Korean journal of family medicine · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- The protective effect of sodium-glucose cotransporter-2 inhibitor on left ventricular global longitudinal strain in patients with type 2 diabetes mellitus according to disease duration.Scientific reports · 2025Article
- Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients.Scientific reports · 2024Article
- Serum uric acid: an independent risk factor for cardiovascular disease in Pakistani Punjabi patients.BMC cardiovascular disorders · 2024Observational
- Elevated blood pressure and hyperuricemia risk: a retrospective cohort study from Wuhu, China.Scientific reports · 2024Article
- Sex Differences in Biochemical Analyses, Cardiometabolic Risk Factors and Their Correlation with CRP in Healthy Mexican Individuals.Journal of personalized medicine · 2024Article
- Managing Gout in Patients with Metabolic Syndrome.Drugs & aging · 2024Review
- Extrahepatic Vitamin K-Dependent Gla-Proteins-Potential Cardiometabolic Biomarkers.International journal of molecular sciences · 2024Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to examine the association of serum uric acid levels with incident cardiovascular disease and mortality in Korean adults without gout.
methodsThis large longitudinal cohort study included adults aged > 19 years who had serum uric acid levels measured at least once at the National Health Insurance Service Ilsan Hospital from January 1, 2006 to December 31, 2015. Longitudinal data on person-level cardiovascular disease and cardiovascular mortality were linked to the National Health Insurance Service claims database and National Death Index.
resultsAmong a total of 92,454 study participants with a median follow-up of 4.7 years, 7,670 (8.3%) composite events of cardiovascular disease or cardiovascular mortality were observed. Multivariable Cox proportional-hazards models revealed that each 1 mg/dL increment in uric acid level was associated with a 6% higher risk of composite outcomes. Compared with that for the uric acid level category of 4.0 to < 5.0 mg/dL, adjusted hazard ratios (95% confidence interval) for uric acid level categories of 5.0 to < 6.0, 6.0 to < 7.0, and ≥ 7.0 mg/dL were 1.10 (1.04-1.18), 1.20 (1.11-1.30), and 1.36 (1.25-1.47), respectively. In the secondary analyses for cardiovascular disease or cardiovascular mortality examined separately, a higher uric acid level was similarly associated with a higher risk of each adverse outcome. These associations were generally consistent across clinically relevant subgroups.
conclusionA graded association was noted between serum uric acid levels and cardiovascular risk, suggesting that higher uric acid levels may adversely affect cardiovascular health and survival in individuals without gout.
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