Evidence map›Paper›PMID 37749885›Full record

ArticleGut microbes2023

Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease.

Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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  17. Frontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Gengfeng LiCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-6314-4226
Jian LinCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiang GaoCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Huiling SuDepartment of Gastroenterology, Linfen Central Hospital of Shanxi Medical University, Linfen, China.
Ritian LinCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Han GaoCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhongsheng FengCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Huili WuDepartment of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Baisui FengDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Keqiang ZuoCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yingchuan LiCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei WuCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Leilei FangCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhanju LiuCenter for IBD Research, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-0326-543X
Tongji University · CNSecond Affiliated Hospital of Zhengzhou University · CNShanxi Medical University · CNZhengzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis enables the establishment of a harmonious gut microenvironment. However, host-derived regulatory networks that modulate intestinal antimicrobial defenses have not been fully defined. Herein we generated mice with IEC-specific deletion of

Indexed as

ColitisGastrointestinal MicrobiomeInflammatory Bowel DiseasesReceptors, G-Protein-CoupledAnimalsHumansHydrogen-Ion ConcentrationInflammationMiceGPR65 protein, humanGPR65 protein, mouseReceptors, G-Protein-Coupledantimicrobial defenseantimicrobial peptideGPR65inflammatory bowel diseaseintestinal epithelial cell

Identifiers

PMID37749885
PMCPMC10524779
OpenAlexW4387034134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.