Evidence map›Paper›PMID 37749587›Full record

SynthesisAlzheimer's research & therapy2023

Cost-effectiveness of physical activity interventions for prevention and management of cognitive decline and dementia-a systematic review.

Weixin Li, Kun-Woo Rafael Kim, Donglan Zhang, Bian Liu, Christine M Dengler-Crish, Ming Wen, Lu Shi, Xi Pan, Yian Gu, Yan Li

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The burden of cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Observational
  15. The economic case for scaling up health research and development: Lessons from the COVID-19 pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weixin Li *Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kun-Woo Rafael Kim *Department of Health Policy, Vanderbilt University School of Medicine, Nashville, TN, USA.
Donglan ZhangDivision of Health Services Research, Department of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, USA.
Bian LiuDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christine M Dengler-CrishDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Ming WenDepartment of Sociology, The University of Hong Kong, Hong Kong, China.
Lu ShiDepartment of Public Health Sciences, Clemson University, Clemson, SC, USA.
Xi PanDepartment of Sociology, Texas State University, San Marcos, TX, USA.
Yian GuDepartment of Neurology, Department of Epidemiology, Columbia University, New York, NY, USA.
Yan LiDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. yanliacademic@gmail.com.

Funding

Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS)R01HL141427 · NHLBI · NEW YORK ACADEMY OF MEDICINE · PI LIU, BIAN, YI, STELLA S · 2018 to 2021
$3.5M
Using machine learning and causal inference approaches to investigate disparities in Alzheimer’s disease and related dementias outcomesR01MD013886 · NIMHD · UNIVERSITY OF GEORGIA · PI ZHANG, DONGLAN · 2019 to 2022
$2.4M
NHLBI NIH HHS R01 HL141427NHLBI NIH HHS R01HL141427NIMHD NIH HHS R01 MD013886NIMHD NIH HHS R01MD013886
6 · The paper itself

Abstract

backgroundAlthough increasing physical activity (PA) has been suggested to prevent and manage cognitive decline and dementia, its economic impact on healthcare systems and society is largely unknown. This study aimed to summarize evidence on the cost-effectiveness of PA interventions to prevent and manage cognitive decline and dementia.

methodsElectronic databases, including PubMed/MEDLINE, Embase, and ScienceDirect, were searched from January 2000 to July 2023. The search strategy was driven by a combination of subject-heading terms related to physical activity, cognitive function, dementia, and cost-effectiveness. Selected studies were included in narrative synthesis, and extracted data were presented in narrative and tabular forms. The risk of bias in each study was assessed using the Consolidated Health Economic Evaluation Reporting Standards and Consensus on Health Economic Criteria list.

resultsFive of the 11 identified studies focused on individuals with existing dementia. Six of the 11 identified studies focused on individuals with no existing dementia, including 3 on those with mild cognitive impairment (MCI), and 3 on those with no existing MCI or dementia. PA interventions focused on individuals with no existing dementia were found to be cost-effective compared to the control group. Findings were mixed for PA interventions implemented in individuals with existing dementia.

conclusionsPA interventions implemented before or during the early stage of cognitive impairment may be cost-effective in reducing the burden of dementia. More research is needed to investigate the cost-effectiveness of PA interventions in managing dementia. Most existing studies used short-term outcomes in evaluating the cost-effectiveness of PA interventions in the prevention and management of dementia; future research should consider adding long-term outcomes to strengthen the study design.

Indexed as

Cognitive DysfunctionDementiaCognitionCost-Benefit AnalysisExerciseHumansAgingCognitive healthCost-effectivenessDementiaExercise

Identifiers

PMID37749587
PMCPMC10519096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.