Evidence map›Paper›PMID 37749347›Full record

ArticleNature chemical biology2024

β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.

Emily E Blythe, Mark von Zastrow

Open access · hybridAbstract read
In one paragraph

Article in Nature chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. The working lives of neuronal 5-HTRSC chemical biology · 2026
    Review
  4. Temporal coding expands the bandwidth of GPCR-mediated neuromodulation.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Mechanisms of Location Bias in G Protein-Coupled Receptors.Handbook of experimental pharmacology · 2026
    Review
  9. Class A and B GPCRs trigger rapid GαCommunications biology · 2025
    Article
  10. Article
  11. Beyond G protein and arrestin: GRK2-biased β₂AR signaling.Trends in pharmacological sciences · 2025
    Article
  12. Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Article
  15. Extensive location bias of the GPCR-dependent translatome via site-selective activation of mTOR.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Beneath the surface: endosomal GPCR signaling.Trends in biochemical sciences · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Emily E BlytheDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6363-2644
Mark von ZastrowDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. mark.vonzastrow@ucsf.edu.ORCID 0000-0003-1375-6926
QB3 · USUniversity of California, San Francisco · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
PROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9M
Membrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6M
Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5M
MEMBRANE TRAFFICKING OF OPIOID RECEPTORSR37DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2004 to 2013
$3.1M
GPR88 localization to primary cilia and its impact on striatal cAMP signalingR01MH120212 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2019 to 2023
$2.0M
MEMBRANE TRAFFICKING OF OPIOID RECEPTORSR29DA010711 · NIDA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VON ZASTROW, MARK E. · 1997 to 2003
$413k
Effects of GPCR trafficking on the spatiotemporal control of signalingF32CA260118 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLYTHE, EMILY ELIZABETH · 2021 to 2023
$189k
NCI NIH HHS F32 CA260118NCI NIH HHS P30 CA082103NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIDA NIH HHS R29 DA010711NIDA NIH HHS R37 DA010711NIMH NIH HHS R01 MH120212NINDS NIH HHS U01 NS120820
6 · The paper itself

Abstract

Many G protein-coupled receptors (GPCRs) initiate a second phase of stimulatory heterotrimeric G protein (G

Indexed as

Peptide HormonesSignal Transductionbeta-Arrestin 1beta-ArrestinsCell Membranebeta-Arrestin 1beta-ArrestinsPeptide Hormones

Identifiers

PMID37749347
PMCPMC10907292
OpenAlexW4387012695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.