ArticleNature medicine2023
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T
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In one paragraph
Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
27.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.Inflammatory bowel diseases · 2025Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Eukaryotic and bacterial gut communities vary along a lifestyle-associated urbanization gradient: comparative analysis of Germany and Madagascar.Gut microbes · 2026Article
- The role ofmBio · 2026Article
- Innate immune recognition ofInfection and immunity · 2026Article
- Antifungal therapy improves microbiome dynamics in inflammatory bowel disease.Nature medicine · 2026Observational
- Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.JCI insight · 2026Article
- Clonal overlap and convergent clustering of T cell receptor signatures in Crohn's disease in monozygotic twins.Inflammatory bowel diseases · 2026Article
- Article
- Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026Article
- Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing.Journal of Crohn's & colitis · 2026Article
- Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation.Gastroenterology · 2026Article
- Canonical pathways and selective mechanisms of autophagy in inflammatory bowel disease.Advanced biotechnology · 2026Review
- Yeast as a Model for Human Disease.International journal of molecular sciences · 2026Review
- ETV1 Drives CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages.Genome medicine · 2026Article
- Chronic neurostimulation of splenic nerve enabled by hydrogel-bioelectronics for wireless electroceutical immunomodulation therapy.National science review · 2026Article
- Noncanonical NF-κB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
37 authors at 6 institutions in 2 countries.
Gabriela Rios MartiniInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Ekaterina TikhonovaInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Elisa RosatiInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-2635-6422
Meghan Bialt DeCelieThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Laura Katharina SieversInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-4677-5181
Florian TranInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-3735-9872
Matthias LessingDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Arne BergfeldDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Sophia HinzInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Susanna NikolausDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Julia KümpersDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Anna MatysiakDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Philipp HofmannInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Carina SaggauInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Stephan SchneidersInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0001-9208-3330
Ann-Kristin KampsInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Gunnar JacobsInstitute of Epidemiology, Christian-Albrechts-University of Kiel and popgen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrechts-University of Kiel and popgen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0003-2544-4460
Jochen MaulGastroenterologie am Bayerischen Platz, Berlin, Germany.
Britta SiegmundDepartment of Gastroenterology, Rheumatology and Infectious Diseases, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-0055-958X
Barbara SeegersGastroenterology-Hepatology Center Kiel, Kiel, Germany.
Holger HinrichsenGastroenterology-Hepatology Center Kiel, Kiel, Germany.
Hans-Heinrich ObergInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Daniela WeschInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Stefan BereswillInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Markus M HeimesaatInstitute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0001-8722-1233
Olaf KniemeyerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.ORCID http://orcid.org/0000-0002-9493-6402
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.ORCID http://orcid.org/0000-0002-8814-4193
Sascha BrunkeInstitute of Microbiology, Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.ORCID http://orcid.org/0000-0001-7740-4570
Bernhard HubeFriedrich Schiller Universität, Jena, Germany.
Konrad AdenInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0003-3482-7316
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Iliyan D IlievThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0884-9749
Alexander ScheffoldInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-0626-343X
Stefan SchreiberInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
Petra BacherInstitute of Immunology, Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. p.bacher@ikmb.uni-kiel.de.ORCID http://orcid.org/0000-0003-4264-6451
Christian-Albrechts-Universität zu Kiel · DEHumboldt-Universität zu Berlin · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEClinical Research Center Kiel · DECornell University · USUniversity of Lübeck · DE
Funding
Commensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2MRegulation and function of mucosal IgA immune responses to mycobiota in the gut.R01AI163007 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2021 to 2025
$2.9MMononuclear phagocyte networks in mycobiota regulation and antifungal immunity.R01DK121977 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2020 to 2024
$2.7MEuropean Research Council 101040023NIAID NIH HHS R01 AI163007NIDDK NIH HHS R01 DK113136NIDDK NIH HHS R01 DK121977NIH HHS R01AI163007NIH HHS R01DK121977
Abstract
Aberrant CD4
Indexed as
Crohn DiseaseInflammatory Bowel DiseasesCD4-Positive T-LymphocytesClone CellsHumansIntestinal MucosaTh17 CellsTh1 CellsT-Lymphocytes, Helper-Inducer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.