ArticleNature immunology2023
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan.
Open access · hybridAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 33 citations in OpenAlex.
- The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire.Aging cell · 2026Article
- Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females.eLife · 2026Article
- The ageing immune system and its battle with viruses.The Journal of general virology · 2026Review
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Cross-reactive antibody and T-cell responses after influenza virus infection in community-dwelling older adults.Journal of virology · 2026Article
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- Vascular Immune Remodeling: A CD4Aging cell · 2026Article
- Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions.BMC medicine · 2026Review
- Meeting Report: Fourth Correlates of Protection for Next Generation Influenza Vaccines.Influenza and other respiratory viruses · 2026Article
- Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood.bioRxiv : the preprint server for biology · 2026Article
- Association of Human Cytomegalovirus exposure with tuberculosis disease in South African adults with presumptive tuberculosis.PLOS global public health · 2026Article
- Review
- Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization of human CMV-specific CD8Cell reports methods · 2025Article
- Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells.Nature communications · 2025Article
- Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope.European journal of immunology · 2025Article
- Linking Epitope-Specific T-Cell Receptors to IFNγ Secretion Using Nanovial Technology.European journal of immunology · 2025Article
- General and individualized changes in T cell immunity during aging.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Age-Related Dynamics and Spectral Characteristics of the TCRβ Repertoire in Healthy Children: Implications for Immune Aging.Aging cell · 2025Article
- Systems Human Immunology and AI: Immune Setpoint and Immune Health.Annual review of immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 8 institutions in 4 countries.
Carolien E van de SandtDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-4155-7433
Thi H O NguyenDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-9294-7693
Nicholas A GherardinDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0003-4690-2571
Jeremy Chase CrawfordDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4096-6048
Jerome SamirSchool of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Anastasia A MinervinaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mikhail V PogorelyyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Simone RizzettoSchool of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-3881-8759
Christopher SzetoViral and Structural Immunology Laboratory, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.ORCID 0000-0003-3784-5210
Jasveen KaurSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.
Nicole RansonSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.ORCID 0000-0003-0677-9919
Sabrina SondaSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.
Alice HarperSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.
Samuel J RedmondDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Hayley A McQuiltenDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-7089-5300
Tejas MenonDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Sneha SantDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Xiaoxiao JiaDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Kate PedrinaVictorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Theo KarapanagiotidisVictorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Natalie CainVictorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Suellen NicholsonVictorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Zhenjun ChenDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0003-1205-683X
Ratana LimObstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
E Bridie ClemensDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Auda EltahlaSchool of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
Nicole L La GrutaImmunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-5358-9363
Jane CroweDeepdene Surgery, Deepdene, Victoria, Australia.
Martha LappasObstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
Jamie RossjohnImmunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-2020-7522
Dale I GodfreyDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7955-0256
Stephanie GrasViral and Structural Immunology Laboratory, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.ORCID 0000-0001-7416-038X
Katie L FlanaganSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, Tasmania, Australia.ORCID 0000-0002-1575-1953
Fabio Luciani *School of Medical Sciences and The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-0666-6324
Katherine Kedzierska *Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. kkedz@unimelb.edu.au.ORCID 0000-0001-6141-335X
The University of Melbourne · AUUniversity of Tasmania · AUSt. Jude Children's Research Hospital · USThe Royal Melbourne Hospital · AUUNSW Sydney · AUAustralian Regenerative Medicine Institute · AULa Trobe University · AUPeter Doherty Institute · AU
Funding
DECODING THE INTERACTIONS BETWEEN T CELL RECEPTORS AND PEPTIDE-MHCR01AI136514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Paul G. Thomas · 2018 to 2026
$6.9MDYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9MNIAID NIH HHS R01 AI136514NIAID NIH HHS U01 AI150747
Abstract
CD8
Indexed as
CD8-Positive T-LymphocytesLongevityAgedEpitopes, T-LymphocyteHumansInfant, NewbornReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaT-Lymphocytes, CytotoxicEpitopes, T-LymphocyteReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-beta
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.