ArticleNature cell biology2023
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
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Article in Nature cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
29 citing papers in PubMed, 32 citations in OpenAlex.
- Non-redundant cardiolipin synthase family proteins shape lipid composition and stress resilience inbioRxiv : the preprint server for biology · 2026Article
- Intracellular growth ofeLife · 2026Article
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- From Iron to Depression: The Crosstalk Between the Periphery and Brain.Neuroscience bulletin · 2026Review
- In vivo visualization of bioactive iron and oxygen using LiON, the labile iron and oxygen notifier.Cell reports methods · 2026Article
- ANP32E drives lung adenocarcinoma progression via GSK3β-mediated glycolytic reprogramming.Cell death & disease · 2026Article
- A kinetic mathematical model of comprehensive iron metabolism in a respiring yeast cell: a basic-pathways approach to solving a large system dynamically.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.bioRxiv : the preprint server for biology · 2026Article
- Iron as an immunometabolic signal in infection and inflammation.Frontiers in immunology · 2026Review
- Characterizing epithelial-mesenchymal transition-linked heterogeneity in breast cancer circulating tumor cells at a single-cell level.Molecular oncology · 2025Article
- Iron and the immune system.Nature reviews. Immunology · 2025Review
- Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis.JHEP reports : innovation in hepatology · 2025Article
- Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.Science advances · 2025Article
- Serum metabolites characterize hepatic phenotypes and reveal shared pathways: results from population-based imaging.Molecular medicine (Cambridge, Mass.) · 2025Article
- Iron deficiency causes aspartate-sensitive dysfunction in CD8Nature communications · 2025Article
- Review
- Metal Ion Signaling in Biomedicine.Chemical reviews · 2025Review
- Decoding iron deficiency in cancer: mechanisms, immune modulation, and therapeutic potential.Frontiers in nutrition · 2025Review
- Identification and experimental validation of demethylation-related genes in diabetic nephropathy.Frontiers in genetics · 2025Article
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Authors and funding
28 authors at 8 institutions in 6 countries.
Jason S Shapiro *Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Hsiang-Chun Chang *Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Yuki TatekoshiFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Zibo ZhaoDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zohra Sattar WaxaliThe Chemistry of Life Processes Institute, Department of Chemistry, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-2615-1221
Bong Jin HongThe Chemistry of Life Processes Institute, Department of Chemistry, Northwestern University, Evanston, IL, USA.
Haimei ChenThe Chemistry of Life Processes Institute, Department of Chemistry, Northwestern University, Evanston, IL, USA.
Justin A GeierFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-1755-1410
Elizabeth T BartomDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-5618-2582
Adam De JesusFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-7491-4732
Farnaz K NejadFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Amir MahmoodzadehFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Tatsuya SatoDepartment of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan.ORCID 0000-0001-7876-1772
Lucia Ramos-AlonsoDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas, Valencia, Spain.
Antonia Maria RomeroDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas, Valencia, Spain.
Maria Teresa Martinez-PastorDepartamento de Bioquímica y Biología Molecular, Universitat de València, Valencia, Spain.ORCID 0000-0002-4128-958X
Shang-Chuan JiangPlant Production and Protection Division (NSP), Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, Rome, Italy.ORCID 0000-0001-7012-5739
Shiv K Sah-TeliBiocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.ORCID 0000-0001-7285-8522
Liming LiDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
David BentremRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Gary LopaschukCardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Issam Ben-SahraDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-9333-4162
Thomas V O'HalloranThe Chemistry of Life Processes Institute, Department of Chemistry, Northwestern University, Evanston, IL, USA.
Ali ShilatifardDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-7490-2854
Sergi PuigDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas, Valencia, Spain.
Joy BergelsonCenter of Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Peppi KoivunenBiocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Hossein ArdehaliFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA. h-ardehali@northwestern.edu.ORCID 0000-0002-7662-0551
Northwestern University · USConsejo Superior de Investigaciones Científicas · ESUniversity of Oulu · FIFood and Agriculture Organization of the United Nations · ITNew York University · USSapporo Medical University · JPUniversitat de València · ESUniversity of Alberta · CA
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MSpatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LICHT, JONATHAN D., O'HALLORAN, THOMAS V · 2015 to 2020
$10.4MDeveloping Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8MTRAINING IN METABOLISM, DIABETES AND ENDOCRINOLOGYT32DK007169 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 1988 to 2026
$6.6MTR&D Project 3: Photoacoustic Detection of Metal Fluxes at the Tissue LevelP41GM135018 · NIGMS · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON, O'HALLORAN, THOMAS V · 2020 to 2024
$5.8MTherapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L., QUAGGIN, SUSAN E. · 2018 to 2022
$5.7MMetalloregulation by MerR and Fur Protein FamiliesR01GM038784 · NIGMS · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 1992 to 2025
$3.5MMechanistic insights into HIV-mediated heart failure with preserved ejection fractionR01HL140973 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 2018 to 2021
$2.6MMechanistic insights into the deleterious effects of SIRT2 in the heart under stress conditionsR01HL138982 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 2018 to 2021
$2.3MRole of mRNA-binding protein tristetraprolin in cardiac mRNA regulation and the development of heart failureR01HL155953 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEINBERG, SAMUEL · 2022 to 2025
$2.3MMechanistic insights into the role of mitochondrial iron in doxorubicin-induced cardiomyopathy using human induced pluripotent stem cellsR01HL140927 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 2020 to 2023
$1.6MNCI NIH HHS P30 CA060553NCI NIH HHS U54 CA193419NHLBI NIH HHS R01 HL127646NHLBI NIH HHS R01 HL138982NHLBI NIH HHS R01 HL140927NHLBI NIH HHS R01 HL140973NHLBI NIH HHS R01 HL155953NIDDK NIH HHS F30 DK109608NIDDK NIH HHS P30 DK114857NIDDK NIH HHS T32 DK007169NIGMS NIH HHS P41 GM108569NIGMS NIH HHS P41 GM135018NIGMS NIH HHS R01 GM038784NIGMS NIH HHS T32 GM008449NIH HHS S10 OD011996NIH HHS S10 OD025194NIH HHS S10 OD026814
Abstract
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here we report a previously undescribed eukaryotic pathway for iron sensing in which molecular iron is required to sustain active histone demethylation and maintain the expression of critical components of the pro-anabolic mTORC1 pathway. Specifically, we identify the iron-binding histone-demethylase KDM3B as an intrinsic iron sensor that regulates mTORC1 activity by demethylating H3K9me
Indexed as
HistonesSignal TransductionDemethylationIronLeucineMechanistic Target of Rapamycin Complex 1Regulatory-Associated Protein of mTORHistonesIronLeucineMechanistic Target of Rapamycin Complex 1Regulatory-Associated Protein of mTOR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.