ArticleNature communications2023
Hydrolase mimic via second coordination sphere engineering in metal-organic frameworks for environmental remediation.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Ce-Doped Lignin-Based Nanozyme with Heat-Activated Hydrolase Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bioinspired Design of Heterogenous Single-Atomic-Site Catalysts for Electrocatalysis and Photocatalysis.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Exploring Fungal Communication Mechanisms in the Rhizosphere Microbiome for a Sustainable Green Agriculture.Journal of fungi (Basel, Switzerland) · 2025Review
- Multi-Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A highly active self-assembled nanozyme based on cascade system for dual-mode detection of sarcosine.Mikrochimica acta · 2025Article
- Surface Engineering-Induced d-Band Center Down-Regulation in High-Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Haloalkane Dehalogenase DhaA Nanoparticle Based on Pullulan Conjugation and Polyethyleneimine Adsorption.Applied biochemistry and biotechnology · 2025Article
- Mimic metalloenzymes with atomically dispersed Fe sites in covalent organic framework membranes for enhanced COChemical science · 2025Article
- Zinc-based Nanomaterials in Cancer Therapy: Mechanisms, Applications, and Future Directions.Theranostics · 2025Review
- LaMgNature communications · 2024Article
- A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity.Research (Washington, D.C.) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzymes achieve high catalytic activity with their elaborate arrangements of amino acid residues in confined optimized spaces. Nevertheless, when exposed to complicated environmental implementation scenarios, including high acidity, organic solvent and high ionic strength, enzymes exhibit low operational stability and poor activity. Here, we report a metal-organic frameworks (MOFs)-based artificial enzyme system via second coordination sphere engineering to achieve high hydrolytic activity under mild conditions. Experiments and theoretical calculations reveal that amide cleavage catalyzed by MOFs follows two distinct catalytic mechanisms, Lewis acid- and hydrogen bonding-mediated hydrolytic processes. The hydrogen bond formed in the secondary coordination sphere exhibits 11-fold higher hydrolytic activity than the Lewis acidic zinc ions. The MOFs exhibit satisfactory degradation performance of toxins and high stability under extreme working conditions, including complicated fermentation broth and high ethanol environments, and display broad substrate specificity. These findings hold great promise for designing artificial enzymes for environmental remediation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.