Evidence map›Paper›PMID 37748892›Full record

ArticleNeurology2023

Performance of a [

Emma M Coomans, Lotte A de Koning, Roos M Rikken, Sander C J Verfaillie, Denise Visser, Anouk den Braber, Jori Tomassen, Marleen van de Beek, Lyduine E Collij, Afina W Lemstra and 9 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Annals of nuclear medicine · 2026
    Article
  4. Article
  5. Review
  6. Evaluation of a Sensitive Visual Read Algorithm for Assessing 3R/4R Tau PET Images.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Article
  8. Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Integrating visual assessments and quantification methods for tau PET staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. Characterizing visual read tau-PET-negative participants with Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Investigating the feasibility ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Observational
  12. Lewy Body Dementia.Continuum (Minneapolis, Minn.) · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 3 countries.

Emma M CoomansFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden. e.coomans@amsterdamumc.nl.ORCID https://orcid.org/0000-0002-4289-9101
Lotte A de KoningFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Roos M RikkenFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Sander C J VerfaillieFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0003-1820-3378
Denise VisserFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Anouk den BraberFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Jori TomassenFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Marleen van de BeekFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0002-1619-073X
Lyduine E CollijFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Afina W LemstraFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Albert D WindhorstFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Frederik BarkhofFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0003-3543-3706
Sandeep S V GollaFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0002-0721-7160
Pieter Jelle VisserFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0001-8008-9727
Philip ScheltensFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0002-1046-6408
Wiesje M van der FlierFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.ORCID https://orcid.org/0000-0001-8766-6224
Rik OssenkoppeleFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Bart N M van BerckelFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Elsmarieke van de GiessenFrom the Radiology & Nuclear Medicine (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Brain Imaging (E.M.C., L.A.d.K., R.M.R., S.C.J.V., D.V., L.E.C., A.D.W., F.B., S.S.V.G., B.N.M.v.B., E.v.d.G.), Amsterdam Neuroscience; Medical Psychology (S.C.J.V.), Amsterdam UMC location University of Amsterdam; Alzheimer Center Amsterdam (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Neurodegeneration (A.d.B., J.T., M.v.d.B., A.W.L., P.J.V., P.S., W.M.v.d.F., R.O.), Amsterdam Neuroscience; Department of Biological Psychology (A.d.B.), Vrije Universiteit Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology & Data Science (W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.
Amsterdam Neuroscience · NLKarolinska Institutet · SELund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesRecently, the US Food and Drug Administration approved the tau-binding radiotracer [

methodsWe included participants who underwent tau-PET at Amsterdam University Medical Center. A subset underwent follow-up tau-PET. Two trained nuclear medicine physicians visually assessed all scans. Inter-reader agreement was calculated using Cohen κ. To examine the concordance of visual read tau positivity with semiquantification, we defined standardized uptake value ratio (SUVr) positivity using different threshold approaches. To evaluate the prognostic value of tau-PET visual read, we performed linear mixed models with longitudinal Mini-Mental State Examination (MMSE).

resultsWe included 263 participants (mean age 68.5 years, 45.6% female), including 147 cognitively unimpaired (CU) participants, 97 amyloid-positive participants with mild cognitive impairment or AD dementia (AD), and 19 participants with DLB. The visual read inter-reader agreement was excellent (κ = 0.95, CI 0.91-0.99). None of the amyloid-negative CU participants (0/92 [0%]) and 1 amyloid-negative participant with DLB (1/12 [8.3%]) were tau-positive. Among amyloid-positive participants, 13 CU participants (13/52 [25.0%]), 85 with AD (85/97 [87.6%]), and 3 with DLB (3/7 [42.9%]) were tau-positive. Two-year follow-up visual read status was identical to baseline. Tau-PET visual read corresponded strongly to SUVr status, with up to 90.4% concordance. Visual read tau positivity was associated with a decline on the MMSE in CU participants (β = -0.52, CI -0.74 to -0.30, DISCUSSION: The excellent inter-reader agreement, strong correspondence with SUVr, and longitudinal stability indicate that the visual read method is reliable and robust, supporting clinical application. Furthermore, visual read tau positivity was associated with prospective cognitive decline, highlighting its additional prognostic potential. Future studies in unselected cohorts are needed for a better generalizability to the clinical population. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that [

Indexed as

Alzheimer DiseaseCognitive DysfunctionLewy Body DiseaseAgedAmyloidAmyloid beta-PeptidesCarbolinesFemaleHumansMalePositron-Emission TomographyProspective StudiesReproducibility of Resultstau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAmyloidAmyloid beta-PeptidesCarbolinestau Proteins

Identifiers

PMID37748892
PMCPMC10663007
OpenAlexW4387008263

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