Evidence map›Paper›PMID 37748888›Full record

ArticleNeurology2023

Association of Neonatal Midazolam Exposure With Hippocampal Growth and Working Memory Performance in Children Born Preterm.

Emma G Duerden, Ting Guo, Cecil Chau, Vann Chau, Anne Synnes, Ruth E Grunau, Steven P Miller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Emma G DuerdenFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada. eduerden@uwo.ca.ORCID https://orcid.org/0000-0002-9734-7865
Ting GuoFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.
Cecil ChauFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.
Vann ChauFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.ORCID https://orcid.org/0000-0001-8260-8738
Anne SynnesFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.
Ruth E GrunauFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.
Steven P MillerFrom the Western University (E.G.D.), London; Hospital for Sick Children (T.G.), Toronto, Ontario; University of British Columbia (C.C., A.S., R.E.G., S.P.M.), Vancouver; and The Hospital for Sick Children and University of Toronto (V.C.), Ontario, Canada.ORCID https://orcid.org/0000-0001-9102-9105
Western University · CA

Funding

CIHR MOP 79262CIHR MOP 86489
6 · The paper itself

Abstract

BACKGROUND AND

objectivesEarly exposure to analgesics and sedatives is a key concern for later learning disorders in children. The hippocampus, a key region for learning and memory, may be selectively affected by exposure to benzodiazepines that are commonly used for sedation, particularly in the neonatal period. In this prospective cohort study, the long-term association of neonatal midazolam exposure, a widely used benzodiazepine in neonatal intensive care, with school age hippocampal growth was examined. Higher-order cognitive function in preterm born children was assessed in relation to hippocampal volumes.

methodsVery preterm born children underwent MRI to characterize the hippocampus and its subfields and neuropsychological testing. Generalized linear models were used to determine the predictors of 8-year hippocampal volumes. Children were assessed on the Wechsler Abbreviated Scales of Intelligence, Second Edition, and the Wechsler Intelligence Scales for Children, Fifth Edition (WISC-V).

resultsA total of 140 preterm children who were 8 years of age participated, and 25 (18%) were exposed to midazolam as neonates. Reduced hippocampal volumes at age 8 years were associated with neonatal midazolam exposure (B = -400.2, 95% CI -14.37 to -786.03, DISCUSSION: Early midazolam exposure and the association with impaired hippocampal growth seem long-lasting and are most apparent in boys. Alterations in subiculum volumes may underlie hippocampus-dependent memory formation processes in preterm born children exposed to midazolam as neonates.

Indexed as

Memory, Short-TermMidazolamBenzodiazepinesChildCognitionFemaleHippocampusHumansInfant, NewbornMagnetic Resonance ImagingMaleProspective StudiesBenzodiazepinesMidazolam

Identifiers

PMID37748888
PMCPMC10663014
OpenAlexW4387008187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.