Evidence map›Paper›PMID 37748832›Full record

ArticleMethods in enzymology2023

Processing macromolecular diffuse scattering data.

Steve P Meisburger, Nozomi Ando

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in enzymology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Scaling and merging macromolecular diffuse scattering with mdx2.Acta crystallographica. Section D, Structural biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Steve P MeisburgerCornell High Energy Synchrotron Source, Cornell University, Ithaca, NY, United States. Electronic address: spm82@cornell.edu.
Nozomi AndoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, United States. Electronic address: nozomi.ando@cornell.edu.

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Protein Allostery and Catalysis Beyond Bragg DiffractionR35GM124847 · NIGMS · PRINCETON UNIVERSITY · PI Nozomi Ando · 2017 to 2026
$4.1M
NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM124847
6 · The paper itself

Abstract

Diffuse scattering is a powerful technique to study disorder and dynamics of macromolecules at atomic resolution. Although diffuse scattering is always present in diffraction images from macromolecular crystals, the signal is weak compared with Bragg peaks and background, making it a challenge to visualize and measure accurately. Recently, this challenge has been addressed using the reciprocal space mapping technique, which leverages ideal properties of modern X-ray detectors to reconstruct the complete three-dimensional volume of continuous diffraction from diffraction images of a crystal (or crystals) in many different orientations. This chapter will review recent progress in reciprocal space mapping with a particular focus on the strategy implemented in the mdx-lib and mdx2 software packages. The chapter concludes with an introductory data processing tutorial using Python packages DIALS, NeXpy, and mdx2.

Indexed as

Macromolecular SubstancesMacromolecular SubstancesData processingDiffuse scatteringReciprocal space mappingSoftwareTutorialX-ray diffraction

Identifiers

PMID37748832

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.