Evidence map›Paper›PMID 37748809›Full record

ArticleLife science alliance2023

KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas.

David Shorthouse, Lizhe Zhuang, Eric P Rahrmann, Cassandra Kosmidou, Katherine Wickham Rahrmann, Michael Hall, Benedict M Greenwood, Ginny Devonshire, Richard J Gilbertson, Rebecca C Fitzgerald and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

David ShorthouseDepartment of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK d.shorthouse@ucl.ac.uk.ORCID https://orcid.org/0000-0002-3207-3584
Lizhe ZhuangInstitute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.
Eric P RahrmannCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-2369-0342
Cassandra KosmidouInstitute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.
Katherine Wickham RahrmannCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0009-0004-7564-9987
Michael HallCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.
Benedict M GreenwoodDepartment of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK.ORCID https://orcid.org/0000-0002-5036-8570
Ginny DevonshireCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.
Richard J GilbertsonCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.
Rebecca C FitzgeraldInstitute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.
Benjamin A HallDepartment of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK b.hall@ucl.ac.uk.ORCID https://orcid.org/0000-0003-0355-2946
University of Cambridge · GBUniversity College London · GB

Funding

Medical Research Council MR/S000216/1Medical Research Council MR/S000216/2Medical Research Council MR/W014122/1
6 · The paper itself

Abstract

Voltage-sensitive potassium channels play an important role in controlling membrane potential and ionic homeostasis in the gut and have been implicated in gastrointestinal (GI) cancers. Through large-scale analysis of 897 patients with gastro-oesophageal adenocarcinomas (GOAs) coupled with in vitro models, we find

Indexed as

AdenocarcinomaKCNQ Potassium ChannelsHumansKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelKCNQ Potassium Channels

Identifiers

PMID37748809
PMCPMC10520261
OpenAlexW4387013651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.