Evidence map›Paper›PMID 37748808›Full record

ArticleBMJ open respiratory research2023

Perinatal and early life factors and asthma control among preschoolers: a population-based retrospective cohort study.

Linn E Moore, Jesus Serrano-Lomelin, Rhonda J Rosychuk, Anita L Kozyrskyj, Radha Chari, Susan Crawford, Jeffery Bakal, Anne Hicks, Francine M Ducharme, Maria B Ospina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Article
  4. Article
  5. Review
  6. Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Linn E MooreDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-0451-460X
Jesus Serrano-LomelinDepartment of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Rhonda J RosychukDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Anita L KozyrskyjDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Radha ChariDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Susan CrawfordAlberta Health Services, Edmonton, Alberta, Canada.
Jeffery BakalAlberta Health Services, Edmonton, Alberta, Canada.
Anne HicksDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Francine M DucharmeDepartment of Pediatrics, University of Montreal, Montreal, Québec, Canada.
Maria B OspinaDepartment of Public Health Sciences, Queen's University, Kingston, Ontario, Canada maria.ospina@queensu.ca.
University of Alberta · CAAlberta Health Services · CAQueen's University · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreventing poor childhood asthma control is crucial for short-term and long-term respiratory health. This study evaluated associations between perinatal and early-life factors and early childhood asthma control.

methodsThis retrospective study used administrative health data from mothers and children born 2010-2012 with a diagnosis of asthma before age 5 years, in Alberta, Canada. The outcome was asthma control within 2 years after diagnosis. Associations between perinatal and early-life factors and risk of partly and uncontrolled asthma were evaluated by multinomial logistic regression.

resultsOf 7206 preschoolers with asthma, 52% had controlled, 37% partly controlled and 12% uncontrolled asthma 2 years after diagnosis. Compared with controlled asthma, prenatal antibiotics (adjusted risk ratio (aRR): 1.19; 95% CI 1.06 to 1.33) and smoking (aRR: 1.18; 95% CI 1.02 to 1.37), C-section delivery (aRR: 1.11; 95% CI 1.00 to 1.25), summer birth (aRR: 1.16; 95% CI 1.00 to 1.34) and early-life hospitalisation for respiratory illness (aRR: 2.24; 95% CI 1.81 to 2.76) increased the risk of partly controlled asthma. Gestational diabetes (aRR: 1.41; 95% CI 1.06 to 1.87), C-section delivery (aRR: 1.18; 95% CI 1.00 to 1.39), antibiotics (aRR: 1.32; 95% CI 1.08 to 1.61) and hospitalisation for early-life respiratory illness (aRR: 1.65; 95% CI 1.19 to 2.27) were associated with uncontrolled asthma.

conclusionMaternal perinatal and early-life factors including antibiotics in pregnancy and childhood, gestational diabetes, prenatal smoking, C-section and summertime birth, and hospitalisations for respiratory illness are associated with partly or uncontrolled childhood asthma. These results underline the significance of perinatal health and the lasting effects of early-life experiences on lung development and disease programming.

Indexed as

AsthmaDiabetes, GestationalAnti-Bacterial AgentsCanadaChildChild, PreschoolFemaleHumansPregnancyRetrospective StudiesAnti-Bacterial AgentsAsthmaAsthma EpidemiologyClinical EpidemiologyPaediatric asthma

Identifiers

PMID37748808
PMCPMC10533801
OpenAlexW4387012446

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.