Evidence map›Paper›PMID 37748554›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients.

Jane J Long, Jennifer D Motter, Kyle R Jackson, Jennifer Chen, Babak J Orandi, Robert A Montgomery, Mark D Stegall, Stanley C Jordan, Enrico Benedetti, Ty B Dunn and 33 more

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In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 1 country.

Jane J LongDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer D MotterDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Kyle R JacksonDepartment of Surgery, Emory University, Atlanta, Georgia, USA.
Jennifer ChenDepartment of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Babak J OrandiDepartment of Surgery, University of Alabama, Birmingham, Alabama, USA.
Robert A MontgomeryDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Mark D StegallDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Stanley C JordanDepartment of Medicine, Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California, USA.
Enrico BenedettiDepartment of Surgery, University of Illinois-Chicago, Chicago, Illinois, USA.
Ty B DunnDepartment of Surgery, University of Pennsylvania, Philadelphia, Philadelphia, USA.
Lloyd E RatnerDepartment of Surgery, Columbia University Medical Center, New York, New York, USA.
Sandip KapurDepartment of Surgery, New York Presbyterian/Weill Cornell Medical Center, New York, New York, USA.
Ronald P PelletierDepartment of Surgery, Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA.
John P RobertsDepartment of Surgery, University of California-San Francisco, San Francisco, California, USA.
Marc L MelcherDepartment of Surgery, Stanford University, Palo Alto, California, USA.
Pooja SinghDepartment of Medicine, Thomas Jefferson University Hospital, Philadelphia, Philadelphia, USA.
Debra L SudanDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Marc P PosnerDepartment of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.
Jose M El-AmmIntegris Baptist Medical Center, Transplant Division, Oklahoma City, Oklahoma, USA.
Ron ShapiroRecanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.
Matthew CooperMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
Jennifer E VerbeseyMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
George S LipkowitzDepartment of Surgery, Baystate Medical Center Springfield, Massachusetts, Massachusetts, USA.
Michael A ReesDepartment of Urology, University of Toledo Medical Center, Toledo, Ohio, USA.
Christopher L MarshDepartment of Surgery, Scripps Clinic and Green Hospital, La Jolla, California, USA.
Bashir R SankariDepartment of Urology, Cleveland Clinic, Cleveland, Ohio, USA.
David A GerberDepartment of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Jason R WellenDepartment of Surgery, Barnes-Jewish Hospital, St. Louis, Missouri, USA.
Adel BozorgzadehDepartment of Surgery, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, USA.
A Osama GaberDepartment of Surgery, Houston Methodist Hospital, Houston, Texas, USA.
Eliot C HeherDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Francis L WengRenal and Pancreas Transplant Division, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Arjang DjamaliDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
J Harold HeldermanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Beatrice P ConcepcionDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kenneth L BraymanDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Jose OberholzerDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Tomasz KozlowskiDepartment of Surgery, University of Florida, Gainesville, Florida, USA.
Karina CovarrubiasDepartment of Surgery, University of California San Diego, San Diego, California, USA.
Allan B MassieDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Mara A McAdams-DeMarcoDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Dorry L SegevDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA; Scientific Registry of Transplant Recipients, Minneapolis, Minnesota, USA.
Jacqueline M Garonzik-WangDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, USA. Electronic address: garonzikwang@wisc.edu.
New York University · USMayo Clinic · USMedStar Heart & Vascular Institute · USUniversity of Virginia · USUniversity of Wisconsin–Madison · USVanderbilt University Medical Center · USBarnes-Jewish Hospital · USBaylor College of Medicine · USBaystate Medical Center · USCedars-Sinai Medical Center · USCleveland Clinic · USColumbia University Irving Medical Center · USCornell University · USDuke Medical Center · USEmory University · USINTEGRIS Baptist Medical Center · USMassachusetts General Hospital · USMemorial Medical Center · USMethodist Hospital · USMount Sinai Hospital · US

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
Structural Racism, Resilience, and Premature Cognitive Aging in End-Stage Renal Disease - Revision - 5R01AG077888 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mara A. McAdams DeMarco · 2022 to 2026
$4.4M
Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Hemodialysis-based interventions to preserve cognitive functionR01DK114074 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2018 to 2022
$3.9M
Quantifying Risk And Survival Benefit from Incompatible Kidney TransplantationR01DK098431 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.7M
Developing personalized immunosuppression for older kidney transplant recipientsR01DK120518 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2019 to 2022
$2.7M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Impact of climate change on cognitive and physical aging of older kidney transplant recipientsK02AG076883 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mara A. McAdams DeMarco · 2023 to 2026
$728k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
Doris Duke Charitable Foundation 2018092NIAID NIH HHS K24 AI144954NIA NIH HHS K02 AG076883NIA NIH HHS R01 AG055781NIA NIH HHS R01 AG077888NIDDK NIH HHS F32 DK113719NIDDK NIH HHS R01 DK098431NIDDK NIH HHS R01 DK114074NIDDK NIH HHS R01 DK120518NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transplant (ILDKT) recipients who undergo desensitization and intense immunosuppression. In a 25-center cohort of ILDKT recipients transplanted between September 24, 1997, and December 15, 2016, we compared mortality, DCGF, delayed graft function (DGF), acute rejection (AR), and length of stay (LOS) between 234 older (age ≥60 years) and 1172 younger (age 18-59 years) recipients. To investigate whether the impact of age was different for ILDKT recipients compared to 17 542 CLDKT recipients, we used an interaction term to determine whether the relationship between posttransplant outcomes and transplant type (ILDKT vs CLDKT) was modified by age. Overall, older recipients had higher mortality (hazard ratio:

Indexed as

Kidney TransplantationAdolescentAdultAgedGraft RejectionGraft SurvivalHLA AntigensHumansLiving DonorsMiddle AgedRisk FactorsYoung AdultHLA Antigensclinical research/practiceHLA-incompatiblekidney transplantationliving donorolderoutcomes

Identifiers

PMID37748554
PMCPMC10767749
OpenAlexW4386987217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.