ArticleNature2023
Distinguishing features of long COVID identified through immune profiling.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06821087 (Evaluating the Neuromodulatory Effect of Ketamine in Long COVID), which is not on this map. Cited by 496 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
496citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms
Who cites it
496 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.Medicine · 2026Pooled it
- Pathophysiological mechanisms of post-exertional malaise: an integrative analysis based on the metabolism-immune-neuro interaction model.Frontiers in immunology · 2026Pooled it
- Losartan and prednisolone for post-COVID syndrome and cardiac inflammation: a randomized, double-blind, placebo-controlled trial.Nature communications · 2026Trial
- Article
- Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection.Brain, behavior, & immunity - health · 2026Article
- Voluntary wheel running behavior is reduced by SARS-CoV-2 S1 administration and mitigates hypothalamic neuroinflammatory processes.Brain, behavior, & immunity - health · 2026Article
- Trends in severe cutaneous adverse drug reactions before, during, and after the COVID-19 pandemic: A retrospective multicenter study of 794 cases.JAAD international · 2026Article
- Neurological Manifestations of Long COVID: Current Evidence, Emerging Concepts, and Future Perspectives.Journal of clinical medicine · 2026Review
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis.Journal of translational medicine · 2026Article
- Reconstructing pathogen-specific antibody binding epitopes and age-dependent immune signatures from proteomic-scale peptide libraries.Science advances · 2026Article
- Persistent cytolytic CD8Cell reports. Medicine · 2026Article
- Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome.Angiogenesis · 2026Article
- Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial.The Lancet regional health. Europe · 2026Article
- Virus reactivation in acute and long COVID-19.Nature · 2026Article
- Article
- COVID-19 Is Airborne AIDS: Provocative Oversimplification, Emerging Science, or Something in Between?AJPM focus · 2026Review
- Beyond Fatigue: The Fatigue Assessment Scale as a Potential Indicator of Long COVID Severity.Journal of clinical medicine · 2026Article
- Emerging trends in post-COVID immune dysregulation: a narrative review.Annals of medicine and surgery (2012) · 2026Review
436 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Update of
Authors and funding
47 authors.
Jon Klein *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3552-7684
Jamie Wood *Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jillian R Jaycox *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Rahul M Dhodapkar *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2014-7515
Peiwen Lu *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6118-872X
Jeff R Gehlhausen *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Alexandra Tabachnikova *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Kerrie GreeneDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Laura TabacofAbilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Amyn A MalikYale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA.
Valter Silva MonteiroDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1785-6713
Julio SilvaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8212-7440
Kathy KamathSerImmune, Goleta, CA, USA.
Minlu ZhangSerImmune, Goleta, CA, USA.ORCID 0000-0003-2347-0569
Abhilash DhalSerImmune, Goleta, CA, USA.
Isabel M OttDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Gabrielee ValleDepartment of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.
Mario Peña-HernándezDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Tianyang MaoDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9251-8592
Bornali BhattacharjeeDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0801-1543
Takehiro TakahashiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1061-356X
Carolina LucasDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4590-2756
Eric SongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5448-5865
Dayna McCarthyAbilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erica BreymanAbilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jenna Tosto-MancusoAbilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yile DaiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7761-3361
Emily PerottiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Koray AkdumanDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Tiffany J TzengDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Lan XuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Anna C GeraghtyDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-3547-237X
Inci YildirimYale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0002-8631-0020
John ShonSerImmune, Goleta, CA, USA.
Ruslan MedzhitovDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7021-2012
Denyse LutchmansinghDepartment of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.
Jennifer D PossickDepartment of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.
Naftali KaminskiDepartment of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5917-4601
Saad B OmerYale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0002-5383-3474
Harlan M KrumholzCenter for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2046-127X
Leying GuanCenter for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.
Charles S Dela CruzDepartment of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5258-1797
David van DijkCenter for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA. david.vandijk@yale.edu.ORCID 0000-0003-3911-9925
Aaron M RingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. aaron.ring@yale.edu.ORCID 0000-0003-3699-2446
David PutrinoAbilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. david.putrino@mountsinai.org.ORCID 0000-0002-2232-3324
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.ORCID 0000-0002-7824-9856
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MViral and immune-mediated CNS pathology during SARS-CoV-2 infectionR01AI157488 · NIAID · YALE UNIVERSITY · PI FARHADIAN, SHELLI, IWASAKI, AKIKO · 2020 to 2024
$4.7MAn integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infectionR35GM143072 · NIGMS · YALE UNIVERSITY · PI VAN DIJK, DAVID · 2021 to 2025
$2.1MFDA HHS U01 FD005938NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI157488NIGMS NIH HHS R35 GM143072NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM136651
Abstract
Post-acute infection syndromes may develop after acute viral disease
Indexed as
Antibodies, ViralHerpesvirus 4, HumanHydrocortisoneLymphocytesMyeloid CellsPost-Acute COVID-19 SyndromeSARS-CoV-2BiomarkersCross-Sectional StudiesHumansImmunophenotypingMachine LearningAntibodies, ViralBiomarkersHydrocortisone
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06821087ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.