Evidence map›Paper›PMID 37748419›Full record

ArticleBiomaterials2023

Complementary modulation of BMP signaling improves bone healing efficiency.

Jiabing Fan, Xiao Zhang, Minjee Kang, Chung-Sung Lee, Lauren Kim, Danny Hadaya, Tara L Aghaloo, Min Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  6. Promoting intervertebral disc fusion using BMP2, L51P, and the EP4 agonist KMN-159: synergistic osteogenesis in human annulus fibrosus cells.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jiabing FanDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA; Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD, 21853, USA.
Xiao ZhangDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Minjee KangDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Chung-Sung LeeDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA; Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, Chungcheongnam-do, 31538, Republic of Korea.
Lauren KimDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Danny HadayaDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Tara L AghalooDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA. Electronic address: taghaloo@dentistry.ucla.edu.
Min LeeDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA. Electronic address: leemin@ucla.edu.
University of California, Los Angeles · US

Funding

Tribbles homolog 3 and BMP-2 induced bone formationR01DE027332 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tara L Aghaloo, Min Lee · 2018 to 2026
$2.7M
Small RNA-Modulated Exosome Mimetics For Craniofacial RegenerationR03DE030539 · NIDCR · UNIVERSITY OF MARYLAND EASTERN SHORE · PI FAN, JIABING · 2021 to 2022
$312k
NIDCR NIH HHS R01 DE027332NIDCR NIH HHS R03 DE030539
6 · The paper itself

Abstract

The bone morphogenetic protein (BMP) signaling pathway plays a crucial role in bone development and regeneration. While BMP-2 is widely used as an alternative to autograft, its clinical application has raised concerns about adverse side effects and deteriorated bone quality. Therefore, there is a need to develop more sophisticated approaches to regulate BMP signaling and promote bone regeneration. Here, we present a novel complementary strategy that targets both BMP antagonist noggin and agonist Trb3 to enhance bone defect repair without the application of exogenous BMP-2. In vitro studies showed that overexpression of Trb3 with simultaneous noggin suppression significantly promotes osteogenic differentiation of mesenchymal stem cells. This was accompanied by increased BMP/Smad signaling. We also developed sterosome nanocarriers, a non-phospholipid liposomal system, to achieve non-viral mediated noggin suppression and Trb3 overexpression. The gene-loaded sterosomes were integrated onto an apatite-coated polymer scaffold for in vivo calvarial defect implantation, resulting in robust bone healing compared to BMP-2 treatments. Our work provides a promising alternative for high-quality bone formation by regulating expression of BMP agonists and antagonists.

Indexed as

Mesenchymal Stem CellsOsteogenesisBone Morphogenetic Protein 2Bone RegenerationCell DifferentiationSignal TransductionBone Morphogenetic Protein 2BMP signalingBone repairNogginSterosomeTrb3

Identifiers

PMID37748419
PMCPMC10805245
OpenAlexW4386885092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.