ArticleProceedings of the National Academy of Sciences of the United States of America2023
Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Systemic and Local Regulation of Root Growth by Vascular Trehalose 6-Phosphate is Correlated With Re-allocation of Primary Metabolites Between Shoots and Roots.Plant, cell & environment · 2026Article
- Evaluating Causal Claims in Plant Developmental Metabolism: A When-Where-How Framework.Plants (Basel, Switzerland) · 2026Review
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Transcriptomic and metabolomic changes associated with the induction and initiation of juice sacs in citrus fruit.Planta · 2026Article
- Transcriptional reprogramming and co-expression network underlying enhanced ammonium uptake in intraspecific hybrids ofFrontiers in plant science · 2026Article
- Context-dependent coordination of TOR and SnRK1 signaling under carbon and nitrogen perturbations.Frontiers in plant science · 2026Article
- Genome-wide identification and expression analysis ofFrontiers in plant science · 2026Article
- Decoding the sugar-strigolactone crosstalk: new frontier in plant growth and stress resilience.Horticulture research · 2026Article
- Glucose-6-Phosphate 1-Epimerase Responds to Phosphate Starvation by Regulating Carbohydrate Homeostasis in Rice andPlants (Basel, Switzerland) · 2025Article
- Trehalose 6-phosphate - a central regulator at the crossroads of sugar signalling, metabolism, and development.The New phytologist · 2025Review
- Simultaneous Knockout of Tk1-SST and Tk1-FFT via CRISPR/Cas9 Enhances the Natural Rubber Accumulation in Taraxacum kok-saghyz.Plant biotechnology journal · 2025Article
- Transcriptomic profiling analysis provides new insights into molecular mechanisms of adventitious rooting recalcitrance in yam vine cuttings.BMC plant biology · 2025Article
- Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase.Plant biotechnology journal · 2025Article
- Transcriptome Analysis Reveals the Role of Trehalose in Response to Polyethylene Terephthalate Nanoplastics Treatment in Foxtail Millet (Food science & nutrition · 2025Article
- Article
- Dihydroxyacetone phosphate generated in the chloroplast mediates the activation of TOR by COScience advances · 2025Article
- Natural variation of indels in the CTB3 promoter confers cold tolerance in japonica rice.Nature communications · 2025Article
- The white lupin trehalase gene LaTRE1 regulates cluster root formation and function under phosphorus deficiency.Plant physiology · 2024Article
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Plant roots explore the soil for water and nutrients, thereby determining plant fitness and agricultural yield, as well as determining ground substructure, water levels, and global carbon sequestration. The colonization of the soil requires investment of carbon and energy, but how sugar and energy signaling are integrated with root branching is unknown. Here, we show through combined genetic and chemical modulation of signaling pathways that the sugar small-molecule signal, trehalose-6-phosphate (T6P) regulates root branching through master kinases SNF1-related kinase-1 (SnRK1) and Target of Rapamycin (TOR) and with the involvement of the plant hormone auxin. Increase of T6P levels both via genetic targeting in lateral root (LR) founder cells and through light-activated release of the presignaling T6P-precursor reveals that T6P increases root branching through coordinated inhibition of SnRK1 and activation of TOR. Auxin, the master regulator of LR formation, impacts this T6P function by transcriptionally down-regulating the T6P-degrader trehalose phosphate phosphatase B in LR cells. Our results reveal a regulatory energy-balance network for LR formation that links the 'sugar signal' T6P to both SnRK1 and TOR downstream of auxin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.