ArticleEnvironmental science & technology2023
Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015.
Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- PFAS: challenges and scientific perspectives in human health risk assessment.Archives of toxicology · 2026Article
- The hidden fluorine: a critical review of analytical methods for unmasking PFAS and closing fluorine mass balance in environmental samples.Analytical and bioanalytical chemistry · 2026Review
- Presence of Legacy and Emerging PFAS in Human Liver Specimens Banked in the United States from 2000 to 2024.Environmental science & technology · 2026Article
- Large declines in organofluorine contamination indicated by subarctic marine mammal tissues.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Per- and Polyfluoroalkyl Substances (PFAS): History, Current Concerns, and Future Outlook.Molecules (Basel, Switzerland) · 2025Review
- Evaluation and comparison of tools used to quantify aggregate PFAS exposure: Extractable organic fluorine, PFAS burden scores and summed PFAS concentrations.Journal of exposure science & environmental epidemiology · 2025Article
- The quest for the perfect "total PFAS" method: how can the total oxidisable precursor (TOP) assay be made reliable?Analytical and bioanalytical chemistry · 2025Review
- Retrospective Identification of Novel and Legacy Per- and Polyfluoroalkyl Substances in German Archived Fish Livers Using a Combined High-Resolution Mass Spectrometry Approach.Environmental science & technology · 2025Article
- Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health.ACS measurement science au · 2024Review
- Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.The Science of the total environment · 2024Review
- Post-ICP Chemical Ionization MS for Total Extractable Organic Fluorine Quantitation.ACS omega · 2024Article
- Combining Advanced Analytical Methodologies to Uncover Suspect PFAS and Fluorinated Pharmaceutical Contributions to Extractable Organic Fluorine in Human Serum (Tromsø Study).Environmental science & technology · 2024Article
- Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans.Environmental science & technology · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Of the thousands of per- and polyfluoroalkyl substances (PFAS) known to exist, only a small fraction (≤1%) are commonly monitored in humans. This discrepancy has led to concerns that human exposure may be underestimated. Here, we address this problem by applying a comprehensive fluorine mass balance (FMB) approach, including total fluorine (TF), extractable organic fluorine (EOF), total oxidizable precursors (TOP), and selected target PFAS, to human serum samples collected over a period of 28 years (1986, 2007, and 2015) in Tromsø, Norway. While concentrations of TF did not change between sampling years, EOF was significantly higher in 1986 compared to 2007 and 2015. The ∑
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